PE-22-28 Peptide CAS 1801959-12-5
Product Name:PE-22-28
Synonym:Gly-Val-Ser-Trp-Gly-Leu-Arg;L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-
CAS NO.:1801959-12-5
EINECS NO.:/
Molecular Formula:C35H55N11O9
Purity & Grade: 99%; Medicine grade
Character:White powder
Free sample:Available
Stock:In stock
Warehouse: USA/EU/AU Warehouse
MOQ & Package: 50mg; Package according to demand
Shipping: Safe and fast delivery
Lead Time: 7-15 days
Store & Shelf life: Cool & dry place; 24 months
Description
Product description
PE-22-28 Peptide CAS 1801959-12-5 is a TREK-1 inhibitor with an IC50 value of 0.12 nM. PE 22-28 is also a 7-amino acid peptide, used as the core sequence for preparing analogs through chemical modification and amino acid substitution. PE 22-28 could be used in research on depression.
Neuroprotection and Repair
PE-22-28 exhibited significant neuroprotective effects in a rodent ischemia model:
Reduced β-cell apoptosis and death
Alleviated stroke-induced motor and cognitive deficits
Improved cognitive function
Studies have shown that PE-22-28 can enhance cognitive abilities through:
Promoting hippocampal neurogenesis, enhancing learning and memory function
Increasing synaptic connection formation, improving neural plasticity
Potential applications in research on neurodegenerative diseases such as Alzheimer's disease, as it increases CREB activity, which is typically downregulated in Alzheimer's disease
Other potential applications
Muscle function research: Trek-1 blockade increases muscle contractility, while activation promotes muscle relaxation, potentially useful in research on diseases such as myogenic bladder dysfunction.
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COA
| Tests | Specifications | Results |
| Appearance | White powder | Conforms |
| MS (ESI) | Conforms | Conforms |
| Purity(HPLC) | ≥98.0% | 98.92% |
| Acetate Content(HPLC) | <12.0% | 9.11% |
| Water Content(Karl Fischer) | ≤10.0% | 2.53% |
| Peptide Content(N%) | ≥80.0% | 84.67% |
| Mass Balance | 95.0~105.0% | 96.31% |
| Conclusion | Conform with enterprise specification | |
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PE-22-28 demonstrated rapid antidepressant effects in a mouse model of depression (within just 4 days), significantly outperforming traditional antidepressants with minimal side effects. Its mechanisms of action include: rapid induction of hippocampal neurogenesis (much faster than existing antidepressants); increased firing rate of 5-Hydroxytryptamine neurons; and enhanced CREB (cAMP response element-binding protein) activity, promoting synapse formation.
Key advantages and features of PE-22-28 Peptide CAS 1801959-12-5
High selectivity: Highly specific for TREK-1 channels, without affecting other two-pore potassium channels such as TREK-2, TRAAK, TASK, and TRESK.
Improved stability: More stable than natural spadin, with a longer half-life, suitable for experimental applications.
Good safety profile: No significant side effects were observed in animal studies; it does not enhance seizures and instead exhibits neuroprotective effects.
Rapid onset of action: Significant effects were observed in depression and neurogenesis models in just 4 days, far exceeding traditional antidepressant products.
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Package
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ
01. What is PE-22-28 Peptide CAS 1801959-12-5?
02. What is the mechanism of action of PE-22-28 Peptide CAS 1801959-12-5?
The main mechanism of action of PE-22-28 is as a specific blocker of TREK-1 potassium channels. TREK-1 channels are expressed in the brain (particularly in areas that regulate mood, memory, and learning, such as the prefrontal cortex and hippocampus) and are typically involved in the regulation of depressive mood by reducing neuronal excitability. By blocking these channels, PE-22-28 increases neuronal excitability, promoting neurogenesis (the generation of new neurons) and synapsis (the formation of new synaptic connections), thereby producing an antidepressant effect.
03. What are the known side effects or safety concerns of PE-22-28 Peptide CAS 1801959-12-5?
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