Elamipretide Peptide CAS 736992-21-5

Elamipretide is a small molecule peptide composed of four amino acids, targeting the mitochondrial inner membrane of SS-31 powder in vivo, which can prevent oxidative damage to nerve cells and other cell types; Pure MTP 131 powder prevents mitochondrial depolarization, reduces pancreatic cell apoptosis, increases pancreatic cell production, and improves post transplant function. Elamipretide peptide powder is a white to off white hygroscopic powder, and special attention should be paid during storage.

The new drug Elamipretide for treating Barth syndrome

Barth syndrome is an extremely rare genetic disorder caused by mitochondrial cardiolipin deficiency, characterized by muscle weakness and cardiac abnormalities, often leading to heart failure, recurrent infections, delayed growth, and shortened life expectancy. There are currently no FDA or EMA approved therapies for treating patients with Barth syndrome.
MTP 131 is a peptide compound designed to penetrate the cell membrane, target the inner membrane of mitochondria, and reversibly bind to phospholipids on the inner membrane of mitochondria. If approved by the FDA, this will be the first marketing authorization for the first mitochondrial targeted therapy drug, Elamipretide.
In addition to Barth's syndrome, the research company stated that Elamipretide is also being developed for the treatment of primary mitochondrial myopathy and is expected to obtain key data for the fully recruited Phase 3 NuPOWER trial by the end of 2024.

Elamipretide (MTP-131) is a mitochondrial targeting peptide that can improve myocardial infarction, enhance renal function, and protect neurons from inflammation and oxidative stress damage.

Elamipretide(MTP-131), as an innovative mitochondrial targeting peptide, has attracted extensive attention in the biomedical field in recent years. This compound not only shows its unique mitochondrial targeting ability, but also shows significant potential in the treatment of many diseases, especially in improving myocardial infarction, improving renal function and protecting neurons from inflammation and oxidative stress.

Improve myocardial infarction: myocardial infarction is a serious cardiovascular disease, which is usually caused by insufficient blood supply to the myocardium caused by coronary artery occlusion. Elamipretide can directly act on damaged myocardial cells, repair mitochondrial inner membrane defects and significantly improve mitochondrial function through its mitochondrial targeting characteristics. Specifically, it can effectively improve the energy metabolism and viability of myocardial cells by increasing complex enzyme activity, reducing the production of reactive oxygen species (ROS), inhibiting apoptosis signal pathway and promoting ATP synthesis, thus alleviating myocardial injury after myocardial infarction and promoting the recovery of cardiac function.

Improve renal function: Elamipretide also shows positive effects in the treatment of renal diseases. As an important excretory and metabolic organ, the impairment of kidney function will seriously affect the quality of life of patients. Elamipretide can protect kidney cells from oxidative stress and inflammatory reaction through its mitochondrial targeting effect, and maintain the normal physiological function of kidney. This is of great significance for the treatment of acute kidney injury, chronic kidney disease and other kidney diseases.

Protect neurons from inflammation and oxidative stress: neurons are the basic structure and functional unit of the nervous system, and their health status is directly related to human cognition, movement, feeling and other functions. However, neurons are easily damaged under unfavorable conditions such as inflammation and oxidative stress. Elamipretide can effectively protect neurons from these unfavorable factors through its powerful antioxidant and anti-inflammatory effects. It can not only reduce the production of ROS, but also inhibit the release of inflammatory factors, thus maintaining the normal structure and function of neurons, which is of great significance for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Clinical trial and safety: At present, Elamipretide has entered the FDA review stage in the United States, and it is expected to be the first drug to treat Barth syndrome. In addition, it is also conducting clinical trials on age-related macular degeneration (AMD), Leber hereditary optic neuropathy (LHON), Duchenne cardiomyopathy and other indications. In clinical trials, the main adverse reactions of Elamipretide in the treatment of patients with Barth syndrome are injection site reactions, including erythema, pain and itching, and most of them are mild to moderate, showing good safety and tolerance.

To sum up, Elamipretide(MTP-131), as a mitochondrial targeting peptide, shows great potential in improving myocardial infarction, enhancing renal function and protecting neurons from inflammation and oxidative stress. With the deepening of research and the advancement of clinical trials, we have reason to believe that Elamipretide will become an important drug for treating many diseases in the future.

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