Spadin Peptide CAS 1270083-24-3

SPADIN is a natural peptide derived from a propeptide released from the bloodstream and is an effective TREK-1 channel blocker with an IC50 value of 10 nM. Studies have shown that Spadin Peptide Powder can block the activity of TREK-1 (KCNK2 or K2P2.1) channels. Spadin specifically binds to TREK-1 to enhance 5-HT neurotransmission in the dorsal raphe nucleus of mice, inducing hippocampal CREB activation and neurogenesis. Clinically, it can mainly be used for the research of antidepressant raw materials.

What are the advantages and disadvantages of Spadin Peptide compared to other TREK-1 channel blockers?

Compared to other TREK-1 channel blockers, spadin has distinct advantages ：
1.High Selectivity: Spadin is a highly selective TREK-1 blocker (IC₅₀ ≈ 10 nM) that does not affect other K2P channels like TREK-2, TRAAK, TASK-1, or TRESK. This specificity is superior to many small-molecule inhibitors (e.g., SID1900, lig4-4) that often have lower affinity and broader off-target effects.
2.Rapid Antidepressant Action: In rodent models, spadin induces antidepressant-like effects within 4 days, a much faster onset than the 2–3 weeks typically required for conventional antidepressants. This rapid action is attributed to its ability to increase 5-HT neuron firing in the dorsal raphe nucleus and promote hippocampal neurogenesis.
3.Favorable Safety Profile: Despite TREK-1 deletion being associated with increased pain sensitivity, seizures, and ischemia, spadin does not induce these side effects in animal models. It also does not affect cardiac function or blood pressure, suggesting a better safety window than non-selective blockers.

Compared to other TREK-1 channel blockers, spadin has distinct disadvantages：

1.Peptide Limitations: As a peptide, spadin has poor bioavailability and a short half-life, limiting its clinical utility. While its retro-inverso analogs and shorter fragments show improved stability and potency, they remain experimental.

2.Limited Clinical Data: Spadin Peptide Powder is still in the preclinical research phase, with no approved clinical applications. In contrast, some non-selective TREK-1 blockers (like： fluoxetine) are already established antidepressants, though they have slower onset and broader side effects

What's the difference between SPADIN Peptide powder and Vortioxetine?

SPADIN and Vortioxetine are two completely different candidate antidepressant pharmaceutical materials in terms of their mechanisms of action, molecular types, and clinical stages. Vortioxetine powder is a marketed small molecule multimodal antidepressant that improves depressive symptoms and cognitive function by inhibiting serotonin (5-HT) reuptake and regulating multiple 5-HT receptors (such as activating 5-HT1A, partially activating 5-HT1B, antagonizing 5-HT3/7, etc.). It is suitable for first-line treatment of adult severe depression, with common adverse reactions such as nausea and headache, but the risk of sexual dysfunction and weight gain is relatively low. SPADIN Peptide powder is a natural peptide still in the preclinical research stage, which enhances 5-HT neurotransmission and promotes hippocampal neurogenesis by selectively blocking TREK-1 potassium channels. It has shown the potential for rapid onset (about 4 days) in animal models, and no significant cardiovascular or pain related side effects have been found. However, due to its peptide properties, its bioavailability is poor and its half-life is short. Currently, it mainly improves pharmacokinetic properties through structural modification, and is still under treatment and has not yet entered clinical application.

A variety of shipping methods for you to choose

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Spadin Peptide Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

FAQ:

Q1: How are the products packaged?​

We use discreet, unmarked outer packaging. Internally, all products are double-sealed in sterile, transparent barrier bags to ensure hygiene and integrity. Our packaging methods have been carefully refined to offer a professional and low-profile appearance.

Q2: Will you confirm the order details with us before shipping?​

Yes. Every item is carefully labeled, and we will reconfirm all order details with you prior to dispatch.

Q3: Is a signature required upon delivery?​

No. Our standard shipping method does not require a signature upon delivery. If you prefer a signature-required service, please contact us in advance to make special arrangements.

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email ：sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

Hot Tags: spadin peptide cas 1270083-24-3, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China