Atosiban Acetate CAS 90779-69-4

Atosiban Introduction

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Atosiban Acetate is a cyclic polypeptide with a disulfide bond composed of 9 amino acids. It is a modified form of oxytocin at positions 1, 2, 4 and 8. The N-terminus of the peptide is 3-mercaptoacetic acid, and the C-terminus is in amide form. The second amino acid at the N-terminus is the ethylated modification [D-Tyr(Et)]2. CAS Number: 90779-69-4; Molecular Formula: C43H67N11O12S2; Molecular Weight: 994.19; EINECS Number: 806-815-5. Its primary application is to delay premature birth.

How does Atosiban inhibit uterine contractions?

Atosiban Acetate is a competitive receptor-blocking polypeptide that can preferentially bind to the Oxytocin and Vasopressin V1A receptors on the uterine smooth muscle, occupying the action sites of endogenous hormones and blocking the downstream intracellular signal transduction mediated by hormones, reducing the release of intracellular calcium ions, weakening the excitability of smooth muscle cells, thereby reducing the tension and frequency of contraction of the smooth muscle and achieving the inhibition of the contraction response.

What are the differences between Atosiban and traditional anti-abortion products?

Compared with the traditional uterine contraction inhibition-related research models, the core differences of Atosiban Acetate lie in its target specificity and the body's tolerance. The former causes less interference to cardiovascular-related indicators. Traditional β₂ receptor agonists lack targeting and affect the entire body system, easily triggering cardiovascular-related reactions such as tachycardia and palpitations. Relevant research data show that the incidence of cardiovascular adverse reactions is higher in the traditional system and it is more likely to be interrupted due to the body's intolerance. However, the probability of related reactions triggered by Atosiban is lower and its tolerance performance is better.
In terms of the observation endpoints related to contraction delay, the overall effects of the two are similar. However, the effects will be affected by the gestational week conditions. Under relatively late gestational weeks, Atosiban does not need to switch to other test substances and the effective proportion is higher than the traditional scheme. In the research on twin pregnancy models, it can achieve a similar effective ratio with β₂ receptor agonists, both superior to the Magnesium sulfate system; at the same time, it takes effect faster and causes less disturbance to heart rate and respiratory-related indicators, with prominent safety advantages.

MF of Atosiban

CAS	90779-69-4
Molecular formula	C43H67N11O12S2
Molecular weight	994.19
EINECS	806-815-5
Density	1.254±0.06 g/cm3

Specification

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FAQ: 

Q1:Is Atosiban safe for the fetus and the newborn?
Clinical data shows it to be relatively safe. As it is not easily able to cross the placental barrier, its direct impact on the fetus is relatively minor. The trials indicate that adverse events in newborns fall within the normal range and have a similar incidence rate to the placebo group.
Q2:What possible adverse reactions may occur after use?

The adverse reactions of the mother are generally mild. The most common one is nausea (with an incidence rate of over 10%); common symptoms include headache, dizziness, hot flashes, tachycardia, and vomiting.

Q3:Can Atosiban be used in the treatment of other diseases?

It is mainly applied in obstetrics. In the frontier exploration, there are basic researches that utilize its molecular regulatory characteristics in experiments related to dysmenorrhea or intervertebral disc degeneration. However, this is still at an extremely early research stage and has not yet become a routine treatment.

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