what is peptide oxytocin?
Peptide oxytocin (CAS 50-56-6, MF C₄₃H₆₆N₁₂O₁₂S₂, MW 1007.19) is a white powder of peptide hormones, which was originally extracted from the posterior pituitary gland of animals such as pigs and cows. Currently, the mainstream method of preparation is through artificial synthesis, with higher purity and fewer impurities. It can effectively stimulate uterine smooth muscle, promote rhythmic contractions of the uterus, and stimulate the contraction of myoepithelial cells around breast acini, promoting milk secretion. It can also act on the cardiovascular system and central nervous system. Widely used in the field of medicine, clinically it is mainly used for full-term induced labor, labor induction, prevention and treatment of postpartum hemorrhage, and acceleration of postpartum uterine involution; It can also be used in animal husbandry, assisting animal delivery, and preventing postpartum uterine diseases. It is a core raw material in the fields of obstetrics, gynecology, and veterinary. reproduction.
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Product name |
oxytocin |
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CAS |
50-56-6 |
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Molecular formula |
C43H66N12O12S2 | |
| EINECS | 200-048-4 | |
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Molecular weight |
1007.19 | |
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Appearance |
white powder |
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| Melting point | 192-194°C | |
| Density | 1.1086 (rough estimate) |
what is the history of peptide oxytocin?
The uterine-contracting properties of the principle that would later be named oxytocin were discovered by British pharmacologist in 1906, and its milk ejection property was described in 1910 and 1911. In 1909 the first clinical use of peptide oxytocin was performed to induce childbirth in patients with complications.
By the 1920s, oxytocin and vasopressin had been isolated from pituitary tissue and given their current names. Oxytocin's molecular structure was determined in 1952. it is the first polypeptide hormone to be sequenced. In 1953, researcher carried out the synthesis of oxytocin, the first polypeptide hormone to be synthesized.
What are functions of peptide oxytocin?
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It can be absorbed from the oral mucosa and selectively act on the smooth muscle of the uterus, promoting uterine contractions. Suitable for delayed birth and labor pains. |
Product Specification
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Item |
Specification |
Test Results |
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Appearance |
White or almost white , hygroscopic powder |
conforms |
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Sequence |
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2(Cys1&Cys6 bridge) |
conforms |
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Solubility |
Very soluble in water. It dissolves in dilute solutions of acetic acid and of ethanol (96 per cent). |
conforms |
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HPLC |
The principal peak in the chromatogram obtained with the test solution is similar in retention time to principal peak in the chromatogram obtained with the reference solution. |
conforms |
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Amino acid analysis |
Asp 0.9-1.1 Glu 0.9-1.1 Pro 0.9-1.1 Gly 0.9-1.1 Leu 0.9-1.1 Ile 0.9-1.1 Tyr 0.7-1.05 Half-Cys 1.4-2.1 No more than the traces of the other acid are present |
Asp 0.95 Glu 0.98 Pro 1.02 Gly 1.03 Leu 0.97 Ile 1.01 Tyr 0.85 Half-Cys 1.55 No more than the traces of the other acid are present |
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PH |
3.0-6.0 (200mg OT in 10ml Of CO2 free water) |
4.6 |
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Related Substances |
Unspecified impurity for each impurity: NMT1.0% |
0.26%(single largest impurity) |
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MS |
1007.2±1.0 |
conforms |
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Acetic acid |
6.0~10.0% |
8.2% |
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Water Content(Karl Fischer) |
NMT 5.0% |
4.1% |
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Assay(By HPLC) |
93.0~102.0% |
98.7% |
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Biological activity (calculated on the basis of 1mg of Oxytocin peptide being equivalent to 600IU of biological activity) |
With reference to anhydrous and acetic acid free substance As is reference |
519IU/mg 522IU/mg |
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Specific Optical Rotation |
-19.5 to -23.5 (C=0.5%; 1% acetic acid) |
-20.12° |
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Residual solvent |
Methanol NMT 3000ppm ;Acetonitrile NMT 410 ppm;Triethylamine NMT 320 ppm |
conforms |
Conclusion：Conform with specification and qualified.
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what is the Biosynthesis of peptide oxytocin?
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The peptide oxytocin is synthesized as an inactive precursor protein from the OXT gene. This precursor protein also includes the oxytocin carrier protein neurophysin I. The inactive precursor protein is progressively hydrolyzed into smaller fragments (one of which is neurophysin I) via a series of enzymes. The last hydrolysis that releases the active oxytocin nonapeptide is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM). The activity of the PAM enzyme system is dependent upon vitamin C (ascorbate), which is a necessary vitamin cofactor. By chance, sodium ascorbate by itself was found to stimulate the production of oxytocin from ovarian tissue over a range of concentrations in a dose-dependent manner. Many of the same tissues (e.g. ovaries,eyes, adrenals, placenta, thymus, pancreas) where PAM (and oxytocin by default) is found are also known to store higher concentrations of vitamin C |
Company profile
FAQ
Q1:What is the solubility of oxytocin powder?
A1:Good water solubility, can be directly dissolved in pure water and acidic aqueous solutions, with fast dissolution rate.
Q2:Does oxytocin have a special odor?
A2:The original powder has a slight odor.
Q3:Is your raw powder extracted from animals or artificially synthesized?
A3:It is an artificially synthesized oxytocin with lower impurity content, stable purity, and no risk of animal derived virus contamination.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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