What is ARA-290 peptide?
Xi'an Faithful BioTech Co., Ltd. is situated in Xi'an, the birthplace of the ancient Silk Road. Leveraging the city's mature logistics network and abundant fine chemical industrial resources, our enterprise has grown into an integrated fine chemical provider that delivers products to global partners. ARA-290 peptide is a linear synthetic polypeptide composed of 11 amino acids, with the sequence pE-Q-L-E-R-A-L-N-S-S-OH. Its molecular structure is designed based on the functional fragment of the Helix-B surface of erythropoietin. Through molecular modification, it acts only on the innate repair receptor (IRR) without promoting erythropoiesis, thus enabling the separation and screening of functional signals. This substance is primarily a white powder with good water solubility and a typical purity exceeding 98%. It is suitable for storage at -20°C in a sealed, light-protected, and dry environment. The innate repair receptor is a heterodimeric protein complex, and its expression is upregulated when cells encounter external stress or tissue damage. ARA-290 can selectively activate this receptor, initiating related intracellular signaling pathways and contributing to research related to cellular state maintenance and tissue recovery.
Application of ARA-290 peptide
ARA-290 peptide(CAS 1208243-50-8), a synthetic polypeptide that selectively activates innate repair receptors, is mainly used in various laboratory research works. It is primarily used to explore neural-related mechanisms, conducting extensive research on small fiber nerve and peripheral nerve sample models. It can also be used for experiments related to receptor signaling pathway analysis, cellular stress response, and vascular and tissue repair. In addition, it is applied to metabolic-related models and corneal nerve sample studies to explore cell survival status, fiber regeneration, and related signaling molecule changes, providing experimental tools for basic research on polypeptide function and receptor interaction mechanisms.
COA
| Test Item | Specification | Test Result |
| Appearance | White Powder | White Powder |
| Purity(HPLC) | ≥98.0% | 99.12% |
| Water Content(Karl Fischer) |
≤5.0% | 2.15% |
| Acetate Content | ≤8.0% | 5.32% |
| Single Impurity | ≤1.0% | 0.45% |
| Total Impurities | ≤2.0% | 0.88% |
| Conclusion | Conform with enterprise specification | |
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Density 1.56±0.1 g/cm3 (Predicted)
Molecular Formula C51H84N16O21
Molecular Weight 1257.31
Exact Mass 1256.599731
LogP -6.59
InChIKey WZTIQQBMSJTRBR-WYKNNRPVSA-N
Mechanism of action of ARA-290 peptide
Receptor-selective recognition: ARA-290 peptide selectively binds to the innate repair receptor IRR, a heterodimeric complex of EPOR and CD131, whose expression is upregulated under tissue stress and injury. The molecular design avoids the classic EPOR homodimer, thus preventing the triggering of erythrocyte proliferation-related signaling pathways.
Intracellular signaling pathway initiation: After binding to the receptor, the peptide activates intracellular signaling cascades such as JAK2-STAT and PI3K/Akt, regulating downstream gene expression, influencing cell viability and cytokine secretion, and modulating local microenvironment signal transduction.
Local microenvironment regulation: It can regulate the expression levels of various cytokines, modulating the activation state of immune cells and microglia, altering the release pattern of local signaling molecules, and improving the microenvironmental conditions in the damaged area.
Cellular state maintenance: Through downstream signaling networks, it helps maintain cellular homeostasis, reduces cell loss caused by external stress, assists various cell types such as nerves and endothelial cells in maintaining normal physiological states, and provides a signaling basis for fibrous structure remodeling.
Regulation of neural signals: It acts on peripheral and spinal cord-related nerve cells, regulates ion channel and glial cell activity, and participates in the regulation of signals related to nerve fiber growth and structural remodeling, providing molecular tools for neural-related model research.
Spatial targeting characteristics: IRR is mainly upregulated in damaged and stressed tissue areas. The signaling effect of the peptide is more concentrated in the perturbed tissue sites, with relatively limited interference to healthy tissues.
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Shipping Methods
| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
| 3-7 days | DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS |
Suitable for under 50kg. International door to door express |
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| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
|
| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
FAQ
01. Which receptor does ARA-290 primarily act on?
It targets the innate repair receptor IRR, which is a heterodimer composed of EPOR and CD131. It does not activate erythrocyte proliferation-related pathways.
02. Which research areas is ARA-290 suitable for?
ARA-290 peptide is primarily used in fundamental experiments such as neural model research, receptor pathway analysis, cellular stress response, tissue repair, corneal nerve studies, and metabolic models.
03. Why doesn't ARA-290 affect erythrocyte-related processes?
The ARA-290 peptide molecule has been modified through fragment selection to recognize only the IRR heterodimer and does not act on the EPOR homodimer; therefore, it does not initiate erythrocyte production-related signaling.
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Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.
Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.
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