XEP-018 Powder CAS 936616-33-0

mu-conotoxin Introduction

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XEP-018 Powder is not a single substance, but a group of polypeptide toxins derived from the venom of tropical marine snails. It is composed of 6 L-Cysteine molecules linked by disulfide bonds to form a stable structure. CAS: 936616-33-0; Molecular formula: C92H139N35O28S6; Molecular weight: 2375.71; EINECS: 606-757-9. These toxins can bind with high affinity and block voltage-gated sodium channels, thereby interfering with the conduction of nerve or muscle excitation. In the field of research, it is mainly used as a tool molecule for distinguishing sodium channel subtypes; at the application level, due to its selectivity for pain-related sodium channels, it is regarded as an important lead compound for non-opioid analgesics, and a few studies have also involved muscle relaxation and skincare fields.

What is the function of mu-conotoxin?

XEP-018 Powder is a sorted and artificially synthesized biological product with extremely potent muscle-relaxing effects. It enables users to experience immediate anti-wrinkle effects and is widely used in anti-wrinkle products. Mu-conotoxin is a highly folded peptide that penetrates strongly, has high stability, and specifically targets muscles to achieve relaxation. By blocking the electrical transmission of nerve-muscle, it instantly fades wrinkles and rejuvenates the skin, making it look younger.

What is the mechanism of action of mu-conotoxin?

The working mechanism of mu-conotoxin can be summarized as a highly specific "molecular blocking" effect. Its molecular structure is tightly locked by three pairs of disulfide bonds, forming a rigid conformation, allowing it to precisely recognize and bind to the receptor site (site 1) on the outer side of the voltage-gated sodium channel pore. Through physical embedding, it blocks the permeation pathway of sodium ions. This binding is equivalent to setting an irreversible barrier at the entrance of the ion flow, effectively preventing sodium ion influx, interrupting the depolarization process of the cell membrane, and ultimately inhibiting the conduction of neural excitation or muscle contraction. It is worth noting that different subtypes of XEP-018 Powder have differential affinities for different sodium channel subtypes from different tissue sources (such as muscle-type NaV1.4 or pain-related NaV1.7). This selectivity stems from the precise spatial matching between specific residues in its amino acid sequence and the channel pore region, enabling them to serve as ideal probes for studying the function of sodium channel subtypes and providing a precise intervention molecular basis for the development of targeted analgesic products.

MF of mu-conotoxin

CAS	936616-33-0
Molecular formula	C92H139N35O28S6
Molecular weight	2375.71
EINECS	606-757-9
Density	1.71±0.1 g/cm3

Specification

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FAQ: 

Q1:Is mu-conotoxin easily absorbed through the skin?
The transdermal permeability of pure peptide molecules is limited. The common solutions currently employed are to use techniques such as liposome encapsulation, microemulsion systems, or ionic electroosmosis to assist in their penetration through the stratum corneum barrier.
Q2:Will mu-conotoxin completely paralyze the facial expression muscles?

No. It is designed to retain approximately 5% of the sodium current, which is equivalent to giving the muscles a little "breathing room", so the facial expression remains natural.

Q3:How long will it take to see the results after using it?

After local application, a visible immediate effect of fine lines reduction usually occurs within a few minutes to 2 hours. This is a type of "instant" line reduction.

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