Tropinone Raw Material CAS 532-24-1

The book "Treatise on Medicinal Properties" records that the herb Tianxianzi has a bitter and pungent taste, a slight heat, and a great toxicity. This herb is widely distributed in the Eurasian continent, and an alkaloid called tropinone was discovered in the analysis of its compounds. According to research, Tropinone Raw Material is a tropane alkaloid, typically needle shaped crystals (in a solvent), commonly used as an intermediate for the synthesis of atropine sulfate. It is also an important alkaloid molecule in the history of organic synthesis, capable of synthesizing most products with similar effects.

What is the pharmacological action of Tropinone Raw Material?

Tropinone can improve nerve cell metabolism, maintain nerve stress ability and reduce blood ammonia. Animal experiments show that free Tropinone Raw Material can excite N- methyl -D- aspartic acid (NMDA) receptors in the brain, cause long-term potentiation, and promote the release of norepinephrine and acetylcholine in the brain. These mechanisms may be related to maintaining nerve stress and enhancing memory.

1) Tropinone can treat motor dysfunction.

Clinically, Tropinone raw powder can promote cell growth and can be used as a nutritional support in the recovery process of high-intensity training (racing, swimming, weightlifting, etc.). By studying the protective effect of Tropinone on motor function nerve in rats with cerebral ischemia, it can inhibit TRAF1, a pro-apoptosis factor, and activate Akt/Bcl-2 signaling pathway, thus delaying neuronal death and improving motor dysfunction.

2)Tropinone can alleviate cerebral ischemia.

Tropinone can protect neurons in hippocampal CA1 area and substantia nigra area in the brain, improve the injury induced by cerebral ischemia-reperfusion, and achieve anti-cerebral ischemia effect. Through the establishment of MCAO model in rats, the results of TH immunohistochemical experiment showed that the number of TH-positive cells per unit area and the cumulative optical density of TH-positive nerve fibers in striatum of Tropinone raw material in the dense area of substantia nigra of rats were significantly higher than those in the model group, while the number of Iba-1 positive cells per unit area in the dense area of substantia nigra of rats was significantly lower than that in the model group.

3)Tropinone in Treating Neurological Insufficiency

Acetylcholine deficiency is the cause of the decline of neurological function, and the concentration of neurotransmitter acetylcholine in cerebral cortex and hippocampus of patients with neurological insufficiency decreased significantly. Tropinone is the activator of nerve cells in the process of nerve cell repair. It urges the nervous system in the brain to decompose more γ -aminobutyric acid (GABA), which can promote the synthesis of acetylcholine, improve brain function, increase the concentration of high-density lipoprotein and accelerate the repair of brain tissue.

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