Tropine CAS 120-29-6

Tropinol, namely α-Tropinol, is an intermediate for the synthesis of atropine. Pure atropine is a white to yellowish crystalline powder, which is an intermediate for the synthesis of many bioactive alkaloids, especially the parasympathetic nerve inhibition of this product is beyond the reach of many similar products. Tropine powder is commonly used in ophthalmology as mydriatic and laxative.

Introduction to the use of Tropine：

Tropine (Pseudotropine, 3alpha Tropanol) is a naturally occurring tropane alkaloid commonly used in the synthesis of various atorvastatin pharmaceutical intermediates, such as Nortropine (also known as Nortropenol), isolated from the total alkaloids of Convolvulus subhirsutus, is an intermediate in tropine breakdown and reactions leading to succinate. In addition, the most commonly used substance in clinical practice is atropine sulfate.
In drug classification, atropine sulfate is an anticholinergic drug that blocks M-cholinergic receptors and belongs to the detoxification drug series. This product can be used to rescue septic shock caused by infection, treat A-S syndrome caused by antimony agents, relieve visceral colic, or be administered before anesthesia.

Where are the latest technological innovations in alpha and beta Tropine ?

α - and β - TROPANOL, which have opposite stereospecificity, are important platform compounds and core building blocks in the biosynthesis and chemical synthesis of (descending) TROPANOL alkaloids. However, the current supply of α - and Pseudotropine still heavily relies on plant extraction or chemical synthesis, which hinders the creation and application of downstream derivatives. The rapid development of synthetic biology helps to solve these challenges, and based on synthetic biology strategies, microbial cell factories can be constructed to synthesize various high-value compounds. Researchers explored the heterologous de novo biosynthesis of α - and β - Pseudotropine using brewing yeast as the host. Based on previous work, the six step biosynthesis pathways of α - and β - Pseudotropine were reconstructed in brewing yeast, and the synthesis pathways were preliminarily optimized. The initial yields of 0.13 mg/L 3alpha-Tropanol and 0.08 mg/L PSEUDOTROPANOL were obtained, respectively. Although they have not yet reached mass production, this not only achieves de novo biosynthesis of Tropine powder, but also provides a platform for chassis cell and enzyme mining for subsequent biosynthesis pathway analysis of their derived alkaloids.

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