Duloxetine HCL Powder CAS 136434-34-9

Duloxetine hydrochloride Introduction

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Duloxetine HCL Powder is a white crystalline substance that is less stable to light, has poor solubility in water, and is unstable in acidic environments, making it easy to degrade. The CAS number of Duloxetine hydrochloride is 136434-34-9. Its molecular formula is C18H20ClNOS and its molecular weight is 333.88. EINECS: 603-962-5.Duloxetine hydrochloride is the hydrochloride form of the antidepressant raw material Duloxetine. The pharmacological effects are basically the same as Duloxetine, both of which are new selective inhibitors of serotonin and norepinephrine reuptake, with antidepressant effects. At the same time, this product has inhibitory effects on central pain.

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What are the pharmacological effects of Duloxetine hydrochloride?

The exact mechanism of LY-248686's antidepressant and central analgesic effects is not yet clear, but it is believed that high-quality Duloxetine hydrochloride solution can enhance the activity of 5-hydroxytryptamine and noradrenergic in the central nervous system. Preclinical studies have shown that Duloxetine hydrochloride powder can effectively inhibit the reuptake of serotonin and norepinephrine, and has low affinity for dopamine reuptake. In mouse experiments, there was no enhancement of seizures caused by special products, and the sensitivity of electroconvulsions was reduced. In vitro studies have found that LY-264453 has no meaningful affinity with dopaminergic, adrenergic, cholinergic, or histaminergic receptors. The pharmacological activity of these receptors is generally believed to be associated with various anticholinergic and sedative effects. There is clear antidepressant activity in animal models, although potential cardiac toxicity cannot be completely ruled out, there is no indication that this is a prominent issue. However, LY-248686 HCl powder can reduce the food intake of animals such as rats, mice, and dogs.

Study on the Effect of Duloxetine in Relieving Cancer Pain

In clinical practice, Duloxetine HCL Powder is a commonly used antidepressant product that can increase certain neurotransmitters to achieve a sense of satisfaction and calmness, used to alleviate depression and generalized anxiety disorder. In addition, this product can also play a significant role in the treatment of neuropathic pain, fibromyalgia, and chronic musculoskeletal pain caused by diabetes, and recent studies have found that this drug also has a certain effect on painful peripheral neuropathy (CIPN) caused by chemotherapy.
During the process of receiving neurotoxic drug chemotherapy, approximately 20% to 40% of cancer patients will experience chemotherapy-induced painful peripheral neuropathy (CIPN). The common clinical manifestations of CIPN are sensory dysfunction and autonomic nervous system disorders (such as numbness in the hands and feet, needle like pain, or difficulty moving), which can persist for months to years after completion of chemotherapy. Their adverse effects on patient function and quality of life pose significant challenges to cancer survivors.
In a quantitative analysis experiment conducted at the University of Michigan, it was found that patients receiving initial treatment with LY-264453 HCl had a significantly higher median reduction in pain scores. Compared with placebo, treatment with 5-week dose of Loxetine can significantly reduce pain.

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FAQ:

Q1:What is the appearance of this raw material?
White to off-white crystalline powder, slightly soluble in water, soluble in methanol and ethanol.
Q2:What structural feature makes it have dual regulatory effects?

It contains naphthalene ring and dimethylamine side chain, blocking transporters to raise 5-HT and NE levels in synaptic space.
Q3:What scientific research scenarios is Duloxetine hydrochloride mainly applicable to?

Experiments about mood-related nerve regulation, chronic neural discomfort and neurotransmitter metabolism.

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