Tadalafil Powder CAS 171596-29-5

Tadalafil Powder is an efficient and long-lasting product for treating ED and BPH, and its "long-lasting" feature provides unparalleled freedom for men's sexual life. According to the statistics of relevant market data, it has become the main product of sexual therapy for adult men, and its mechanism of action is to inhibit the degradation of PDE5, leading to the accumulation of cGMP, relaxing the smooth muscle of the corpus cavernosum and leading to penile erection. In addition, API Tildenafil powder has a relatively wide range of functions and is often used to deal with pulmonary hypertension in clinic.

What is the mechanism of action of Tadalafil Powder?

Tadalafil Powder works by selectively inhibiting phosphodiesterase -5(PDE5). Preclinical studies have found that it can selectively act on PDE5, but has little effect on other PDE isoenzymes such as PDE1, PDE2, PDE3, PDE4 and PDE6. In clinic, it is mainly used for erectile dysfunction and pulmonary hypertension:
1. Erectile disorder: As a commonly used selective phosphodiesterase type 5 (PDE5) in the market, hot-sale tadalafil powder is different from most similar products in molecular structure, and high-fat diet will not interfere with its absorption. We know that nitric oxide synthase (NOS) in penile nerve endings and vascular endothelial cells catalyzes the synthesis of nitric oxide (NO) from L-arginine. NO activates guanosine cyclase, which transforms guanosine triphosphate into cyclic guanosine phosphate (cGMP), thus activating cyclic guanosine phosphate-dependent protein kinase, which leads to the decrease of calcium ion concentration in smooth muscle cells, which relaxes the smooth muscle of corpus cavernosum and causes erection. In this process, phosphodiesterase type 5 (PDE5) will also be produced in the body, and cGMP will be degraded into a physiologically inactive product, which will turn the penis into a weak state. calais is different from other products in that it does not achieve its goal by increasing the normal pathway of nitric oxide synthase, but by inhibiting PDE5 degradation.

2. Pulmonary hypertension: Tildenafil is a potent, reversible and highly selective phosphodiesterase -5(PDE-5) inhibitor, which can dilate pulmonary vessels through NO/c GMP and also reduce pulmonary artery pressure.

What is the synthesis method of Tadalafil Powder?

Starting from D-tryptophan, D-Tryptophan methyl ester hydrochloride is first subjected to methylation reaction. The resulting D-Tryptophan methyl ester hydrochloride undergoes Pictet-spengler reaction with a certain aldehyde complex in Isopropyl alcohol to obtain a cis tetrahydrocarboline compound. It is then sequentially reacted with Chloroac etyl chloride and catalyst, with a total yield of 56%. After screening, Acetic acid is used as a recrystallization solvent for further purification.

What are the core features and advantages of Tadalafil Powder?

1. Long-lasting: This is the most remarkable feature of tadalafil. Its effect can last as long as 36 hours. This provides a greater spontaneity for partners, and there is no need to strictly plan the time of use and sex life.

2. Not affected by diet: Unlike some similar products of the same kind, high-fat foods will not significantly affect the absorption and efficacy of tadalafil, and can be taken with or without meals.

3. Once a day: Tildenafil only needs to be used once as needed with some drugs of the same kind, and it is very friendly for men who have frequent sexual life (more than twice a week).

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Tadalafil Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

FAQ:

Q1. What is tadalafil?
Tadarafe is mainly used to treat erectile dysfunction (ed) and benign prostatic hyperplasia (BPH). It belongs to a class of pharmaceutical intermediates called phosphodiesterase type 5 (PDE5) inhibitors.

Q2. Is tadalafil safe for men with heart problems?
Men with cardiovascular disease must be evaluated before prescribing tadalafil. Sexual activity can put pressure on the heart. Your doctor will determine whether your heart is healthy enough to have sex and use this medicine.

Q3. Is the generic drug tadalafil as effective as the trade name Cialis?
Yes Ordinary tadalafil contains exactly the same active ingredients as brand Cialis. It is approved by FDA, which is also safe and effective, but the cost is much lower.

Q4. Can I use food with tadalafil?
Yes, tadalafil can go with food. Moreover, high-fat meals will not significantly delay its absorption.

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