Rivastigmine Hydrogen Tartrate CAS 123441-03-2

Rivastigmine Hydrogen Tartrate CAS 123441-03-2

Product Name:Rivastigmine
CAS.NO:123441-03-2
Molecular Formula:C14H22N2O2
EINECS.NO:602-936-0
Synonym:Revastigmine;S-RivastigMine;RivastigiMine;Rivastigmine base;Revastigmine
Test Method:HPLC/UV
MOQ & Package: 10g,100g,1kg etc Sub-package
Certificate:FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time: 1-3 days
Shipping: DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life; Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Send Inquiry
Description

According to the research of modern medicine, the cerebral cortex choline of patients with Alzheimer's disease is far below the normal level, so as long as we can increase the concentration of acetylcholine, the cognitive function of these patients can be improved. Rivastigmine is a selective acetylcholinesterase inhibitor, which can selectively inhibit acetylcholinesterase in the central nervous system, and then inhibit the metabolism of acetylcholine in the postsynaptic space, thus enhancing the transmission of cholinergic nerve signals. Moreover, its inhibitory effect is targeted and will not have any influence on the enzymes of other surrounding tissues. Rivastigmine Hydrogen Tartrate provided by us has been approved for marketing in the United States, and it is an important intermediate for the treatment of Alzheimer's disease in many factories.

Item

Specification

Results

Appearance

white to light yellow powder

White powder

Purity (HPLC)

NLT 98.0%

99.17%

Related substances (HPLC)

Total impurities: NMT 2.0%

Maximum single impurity: NMT 1.0%

0.83%

0.34%

Acetic acid Content (HPLC)

NMT   15.0%

N.D

TFA Content (HPLC)

NMT   1.0%

N.D

Water Content (K.F)

NMT   8.0%

7.43%

pH

Reported value(C=5mg/ml)

8.50

Residue solvents(GC)

Acetonitrile NMT 410ppm

Methanol NMT 3000ppm

Methylene chloride NMT 600ppm

Isopropyl ether NMT 5000ppm

N,N-Dimethylformamide  NMT  880ppm

91ppm

26ppm

N.D

13ppm

N.D

Oligomer

NMT   3.0%

N.D

Bacterial Endotoxins

NMT  10 EU/mg

Conforms

Microbial Limits

TAMC NMT 50 cfu/0.1g

TYMC NMT 50 cfu/0.1g

Conforms

Conforms

Conclusion:

Conform with enterprise specification .

 

 

What is Rivastigmine Hydrogen Tartrate?

Revastigmine is a second-generation cholinesterase inhibitor, and its inhibitory effect on central AchE is stronger than that on peripheral acetylcholinesterase (AchE). It can also inhibit butyrylcholinesterase. Clinically, products made from S-RivastigMine API Powder are effective for patients with mild to moderate AD, especially for AD patients with diseases such as heart, liver and kidney. The latest research indicates that RivastigiMine has a highly selective effect in the hippocampus and cortical regions of the brain and can also slow down the formation of amyloid p-amyloid precursor protein (APP) fragments. We know that amyloid plaques are one of the main pathological features of Alzheimer's disease. Therefore, the rational use of Rivastigmine Hydrogen Tartrate can significantly improve cognitive abilities such as memory, attention and sense of direction. Of course, it also has some drawbacks such as nausea, vomiting, diarrhea, fatigue, dizziness, drowsiness and mental confusion.

 

What are Rivastigmine Hydrogen Tartrates effects and damage mechanisms respectively?

Animal experiment results show that Revastigmine powder can selectively enhance the effect of acetylcholine in the cerebral cortex, hippocampus and other parts. Therefore, Rivastigmine base powder can improve cholinergic cognitive dysfunction in patients with Alzheimer's disease. In large mammals, the activity of acetylcholinesterase in cerebrospinal fluid (CSF) decreased by nearly 40% within about 1.5 hours after its use. It takes about 9 hours for the enzyme activity to return to the basic level after the drug achieves its inhibitory effect. In clinical trials, we can observe that the inhibitory effect of S-RivastigMine in the CSF of patients with Alzheimer's disease on acetylcholinesterase is dose-dependent.Rivastigmine can turn back your memory time!
Unlike other acetylcholinesterase inhibitors, it is hardly metabolized by the liver. However, more experimental data are still needed for the hepatotoxicity mechanism of Rivastigmine Hydrogen Tartrates.

 

How long does it take to see the effect after using Rivastigmine Hydrogen Tartrates?

The time it takes for the effect to show varies from person to person. Some patients may notice some improvements (such as a reduction in behavioral symptoms) within a few weeks, but it usually takes several months of continuous treatment to produce a relatively significant and stable effect on cognitive functions (such as memory and attention).
Importantly, the main goal of Rivastigmine Hydrogen Tartrates is to delay the decline. The so-called "effect" may manifest as the condition remaining stable or the rate of deterioration slowing down, rather than a reversal of the situation.

 

A variety of shipping methods for you to choose

Transportation Time

Shipping method

Cargo weight requirements

Advantage

3-7 days

DHL,Germany DHL,Germany DPD,
UPS,USPS,FedEx,TNT,EMS

Suitable for under 50kg.
International door to door express

We have warehouses in Germany and California, USA,
and customers in Europe and America can
enjoy sending goods directly from these two places.

7-15 days

By Air

Suitable for more than 50kg.
fast and cheaper for large order

15-60 days

By Sea

Suitable for more than 500kg.
Cheapest shipping way

 

Our strengths:

Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Rivastigmine Hydrogen Tartrate Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

 

FAQ:

Q1: What diseases is Rivastigmine base mainly used for?
It is mainly applicable to:
1. Mild to moderate Alzheimer's disease.
2. Dementia associated with Parkinson's disease

Q2: Is there any conflict between Rivastigmine Hydrogen Tartrate and other products?
Yes. According to the experiments of different animals, you may encounter the following problems that need attention:
1. If it encounter other cholinesterase inhibitors (Donepezil, Galanthamine) or some anesthetics for treating Alzheimer's disease, The experimental object may increase the risk of side effects.
2. If a product with an opposite effect to that of API Rivastigmine is encountered, its therapeutic effect will be reduced. For instance, certain raw materials for treating allergies (Diphenhydramine), gastrointestinal spasms (L-Hyoscyamine), and Parkinson's disease (Piribedil).
3.It may increase the risk of bradycardia when used with beta blockers (used to treat hypertension and heart disease).
Q3: Can S-RivastigMine Cure Alzheimer's Disease?
it can't. S-RivastigMine can improve and stabilize patients' cognitive function and behavioral symptoms, improve the quality of life and delay the process of functional decline, but it can't stop the final progress of the disease.

 

Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.

If you are interested in our products, or have critical suggestions on our articles or are not completely satisfied with the products received, please contact us by Email :sales6@faithfulbio.com   . Our team is committed to ensuring the complete satisfaction of customers.

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