Raw Tofacitinib Citrate Powder CAS 540737-29-9

Raw Tofacitinib citrate powder is a new Janus kinase inhibitor developed in Pfizer, USA. It can be used in combination with methotrexate to treat active rheumatoid arthritis with insufficient response to tumor necrosis factor inhibitors. In addition, it also has a very good effect on the single treatment of rheumatoid arthritis, ulcerative colitis, psoriasis and other inflammation-related diseases. The effect of its products has also been affirmed by the American market, and it was approved for listing by the US FDA on November 7, 2012.

What is the pharmacological action of Raw Tofacitinib citrate powder ?

Research has found that the JAK inhibitor Raw Tofacitinib citrate powder can effectively inhibit the activity of JAK1 and JAK3, blocking the signaling of various inflammatory cytokines. The treatment is highly effective in treating moderate to severe rheumatoid arthritis (RA) patients who are in the active phase of adulthood and have poor response to Methotrexate (MTX). And unlike most other RA treatment drugs currently available, Tasocitinib citrate mainly acts on extracellular targets. CP 690500-10 targets the intracellular signaling pathway and acts on the core part of the cytokine network. Therefore, the inhibitory intensity of tofacitinib on JAK3 is 5-100 times that on JAK1 and JAK2. The FDA states that patients with moderate to severe rheumatoid arthritis can use tofacitinib alone or in combination with methotrexate 59-05-2 and other specific standard treatment drugs.

What's the point of using Raw Tofacitinib Citrate Powder ?

Nausea and gastrointestinal discomfort are the most common adverse reactions of CP 690500-10, but with the long-term use of this product, most patients can gradually adapt to it, and different forms of use of this product will also have an impact on the product.
In addition, Tofacitinib citrate powder has certain hepatotoxicity, which will lead to a transient increase in transaminase. If it is taken for a period of time and gradually returns to normal, it can continue to be used. However, if the transaminase level is more than 3 times higher than the normal upper limit, the treatment of this product needs to be terminated. As a classic drug, Raw Tofacitinib Citrate Powder is relatively safe under the correct guidance of doctors.

What is the application status of Raw Tofacitinib Citrate Powder?

Bone marrow fibrosis (MF) is a very rare disease, which will destroy normal blood cell production. Can cause anemia, weakness, fatigue, spleen and liver swelling and other symptoms. There is no clear answer to the cause of the disease. The typical clinical manifestations are erythrocytic anemia and granulocytic anemia, and there are many teardrop-shaped erythrocytes. Dry pumping often occurs during bone marrow puncture, and the spleen is often obviously swollen, with different degrees of sclerosis.
Tofacitinib citrate, a tyrosine kinase inhibitor of JAK1 and JAK3, was approved by the European Union in August 2012 to treat moderate or high-risk myelofibrosis, including primary myelofibrosis, myelofibrosis after polycythemia vera and myelofibrosis after thrombocytosis. At present, Raw Tofacitinib Citrate Powder has been approved by more than 50 countries around the world, including the European Union, Canada and some countries in Asia, Latin America and South America.

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