Raw Powder Escitalopram Oxalate CAS 219861-08-2

(S)-CITALOPRAM is the S-isomer metabolite of Citalopram and the main component responsible for its pharmacological activity. It is a selective serotonin reuptake inhibitor with good therapeutic effects on both endogenous and non endogenous depression. In clinical practice, we often refer to white or off white Raw Powder Escitalopram Oxalate as the "sixth golden flower" of antidepressants because of its high safety, minimal side effects, low risk of drug resistance, and no contraindications to drug compatibility. It is particularly suitable for elderly patients with multiple physical illnesses.

What are the pharmacological effects of Raw Powder Escitalopram Oxalate? 

Compared to Citalopram, (S) - Citalopram has a better effect in selectively inhibiting the reuptake of serotonin by central nervous system neurons, and has a smaller impact on the reuptake of norepinephrine and dopamine. It is a commonly used clinical product. According to relevant data, in terms of inhibition of serotonin reuptake, the activity of Escitalopram Oxalate is at least 100 times stronger than 59729-33-8 Citalopram hydrobromide (right-handed form), and adverse reactions are almost negligible. (S) Citalopram-d6 has no or very little effect on serotonin 1-7 receptors or other receptors including alpha and beta adrenergic, dopamine 1-5, histamine, etc. It also has no effect on Na+, K+, Cl -, and Ca2+ion channels. It is highly suitable for individuals with physical illnesses accompanied by depression and requiring the combination of multiple medications, as there is no significant response from the cardiovascular system. At the same time, in animal experiments, researchers found that Raw Powder Escitalopram Oxalate also has the ability to resist platelet aggregation, protect endothelial function, reduce inflammatory reaction, and then prevent the occurrence and development of atherosclerosis and stabilize plaque; In addition, it can effectively stabilize myocardial oxygen consumption, thereby improving coronary blood supply and alleviating coronary symptoms.

What is the difference between Raw Powder Escitalopram Oxalate and sertraline?

Escitalopram oxalate and sertraline are both serotonin reuptake inhibitors, which can be used to treat depression and anxiety, and may even be combined when the effect of single drug is not good. What is the difference between the two drugs? How to choose correctly?

1. The two product have different degrees of diseases.

Sertraline is the first choice for the treatment of mild depression, anxiety or anxiety with sleep disorder, which is mainly used for the treatment of mild depression and anxiety or the early stage of the disease; ESCIFALOPRAMOXALATE is mainly used for moderate and severe depression and generalized anxiety disorder. The degree of the disease it treats is often severe, and the course of the disease is often long. Most of them choose to take other antidepressants after their effects are not good.

2. The pharmacokinetics of the two product are different.

The effect of sertraline is very slow, and it takes about 8 hours to achieve obvious effect, and it takes more than 2 weeks to achieve a stable therapeutic effect. Moreover, sertraline is mainly metabolized and excreted by the kidney, so renal function has a great influence on sertraline metabolism. 98% purity Escitalopram oxalate takes effect quickly, and it can take effect about 2 hours after use, and the drug concentration can reach a stable level after continuous use for 1 week. Moreover, the liver is the main metabolic organ of Citalopram, so the liver function has a greater influence on Citalopram.

3. In contrast, Escitalopram oxalate has fewer side effects.

(S)-CITALOPRAM is the most selective drug among all serotonin reuptake inhibitors, and it has little effect on other neurotransmitters, so its side effects are far less than sertraline, but because of this, the price of (S)-Citalopram-d6 is higher.
It needs to be emphasized here that depression is a common and recurrent psychological disorder. According to modern medical research, the causes of depression include genetic factors, biochemical factors and psychosocial factors, and the initial performance is not obvious, which often misses the best period of treatment, thus leading to chronic, long-term, stubborn and easy to relapse of depression. Patients with mild depression lack interest in everything, while those with severe depression have slow response, decreased memory and attention, pessimism and despair. Therefore, there is no standard treatment plan for anti-anxiety and depression drugs, but only the most suitable treatment plan. Because different people have different sensitivities and specificities for drugs, we must pay attention to individualized medication, listen to the professional guidance of doctors, and do not blindly change drugs or stop taking drugs without authorization.

To sum up, Raw Powder Escitalopram Oxalate is the first-line drug for the treatment of moderate and severe depression and generalized anxiety disorder. Compared with sertraline, it has strong efficacy and few side effects, but it is personalized and needs to be standardized under the guidance of doctors. Secondly, we must pay attention to the dosage of the product and the cross-reaction with other drugs during taking; Finally, we must pay attention to the adverse reactions of drugs, respond to doctors in time once they appear, and make positive treatment.

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