Edaravone Powder CAS 89-25-8

Edaravone Powder is a new free radical scavenger, which is suitable for improving the neurological abnormalities caused by acute cerebral infarction. Because its molecular structure contains lipophilic groups, it can easily reach the brain tissue through the blood-brain barrier, and it has a protective effect on nerve cell damage caused by cerebral ischemia. In addition to its own Medical capability, Hot sales Edaravone is also an intermediate for the synthesis of various pharmaceutical and chemical raw materials, such as dyes such as Mordant Bordeaux BN, Permanent yellow G and Leather spray red G, and reagents for the determination of cobalt, copper, iron, nickel, silver and vitamin B12.

What is the mechanism of action of this product?

The mechanism of Edaravone's neuroprotective effect on nerve cells mainly involves clearing oxygen free radicals, inhibiting lipid peroxidation, regulating inflammatory factors, thereby inhibiting brain cell apoptosis, oxidative damage to vascular endothelial cells and nerve cells, etc. Clinical studies suggest that N-acetylaspartic acid (NAA) is a specific marker of surviving nerve cells, and its content decreases sharply in the early stages of cerebral infarction. If appropriate Edaravone powder is given during the acute phase of cerebral infarction, it can inhibit the reduction of local cerebral blood flow around the infarction, resulting in a significant increase in NAA content in the brain on the 28th day after onset compared to the glycerol control group. In animal experiments, we have found that administering Edaravone to rats under ischemia can prevent the progression of cerebral edema and infarction, alleviate accompanying neurological symptoms, and inhibit delayed neuronal death.

What is the market prospect of this product?

Among numerous neurological products, edaravone is currently the only neuroprotective agent with sufficient evidence-based medicine. The Phase III clinical trial conducted in Japan has confirmed that edaravone can effectively improve patients' neurological function prognosis. This study is a multicenter, randomized, double-blind, placebo-controlled clinical trial with a high level of evidence. The "Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke (2014 Edition)" states that edaravone is an antioxidant and free radical scavenger. Multiple randomized double-blind placebo-controlled trials at home and abroad have suggested that edaravone can improve the functional outcomes of acute cerebral infarction and is safe (Level I recommendation, Level B evidence). The "Japanese Stroke Treatment Guidelines 2015" published in 2017 pointed out that edaravone (an antioxidant drug) can effectively improve the prognosis of patients with acute cerebral infarction (within 72 hours of onset). Stratified analysis showed that edaravone has better efficacy in patients with cerebral infarction within 24 hours of onset, and therefore has been approved for use in Japan (level 2, with only alteplase and aspirin recommended at level 1), and edaravone powder is the only recommended neuroprotective agent in this guideline. Europe is currently conducting Phase 2 clinical trials.

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