Cycloastragenol Powder CAS 84605-18-5

Cycloastragenol belongs to the triterpenoid saponin class, mainly obtained by hydrolysis of astragaloside IV. The substance appears as colorless needle shaped crystals with a density data of 1.20 g/cm ³. Cycloastragenol powder is currently the only discovered telomerase activator, which delays telomere shortening by increasing telomerase activity. Therefore, it is considered to have anti-aging effects

What is telomerase activator?

Telomeres are constantly shortened due to incomplete chromosome replication, and when they reach a critical value, they can trigger DNA damage signals, leading to a shortened cell cycle and a series of tissue failure diseases characterized by short telomeres. Studies have found that many diseases, including ischemic brain injury, diabetes complications, idiopathic pulmonary fibrosis, osteoporosis and so on, are related to telomere dysfunction.Reportedly, Cycloastragenol (CAG) is a glycoside of Astragaloside IV and the only reported telomerase activator in natural products. It can effectively combat telomere shortening, and has pharmacological effects such as anti-aging, anti apoptosis, anti fibrosis, immune regulation, promotion of cell proliferation and wound healing. Therefore, it has potential therapeutic effects on telomere dysfunction related diseases.

How to activate telomerase?

Many natural compounds can be used as activators of telomerase. In Europe and America, the most famous product is TA-65, and many people have heard of it.
1. Astragalus extract
The main component of TA-65 is Astragalus extract. The developer thinks that TA-65 is a "weak telomerase activator" and safe, but the effect may not be ideal.
2. Resveratrol and Xylophone.
Studies have found that some phytochemicals, such as resveratrol and genistein, can activate telomerase. Appropriate dose can down-regulate telomerase activity and hTERT level in MCF7 breast cancer cells.
However, high concentration of resveratrol can inhibit cell proliferation. Relatively high concentration of resveratrol can down-regulate telomerase activity in human colon cancer cells and slow down the incidence of colon cancer diseases.
According to the latest research, resveratrol can inhibit telomerase activity in cancer cells and activate telomerase in epithelial and endothelial progenitor cells through Akt-dependent mechanism, thus slowing down the aging of endothelial progenitor cells.
3: Curcumin and Curcumin-like Derivatives
Curcumin is a natural polyphenol compound extracted from turmeric, which can enhance telomerase activity. It plays a key role in enhancing the affinity between telomerase and telomere DNA.
It has been found that many curcuminoid derivatives can enhance telomerase activity in TRAP assay in vitro.
4: cycloastragenol
Cycloastragenol powder is a triterpenoid saponin compound, which is the hydrolysis product of the main active components of Astragalus.
It was found that cyclosporin CAG was mainly involved in two kinds of cell signaling pathways:
One pathway includes phosphorylation of extracellular signal-regulated kinase (ERK) and up-regulation of telomerase expression through ERK pathway. The other pathway induces the expression of Janus kinase 2(JAK2) and STAT5b, and regulates the expression of telomerase through JAK/STAT. CAG is safe and effective in maintaining telomere activity and prolonging telomere length.
5: Centella asiatica extract preparation
It was found that Centella asiatica extract preparation (08AGTLF) can induce telomerase activation and prolong telomeres in peripheral blood mononuclear cells of healthy donors.
6. Natural compounds such as allicin
It was found that various compounds naturally occurring in plants, such as allicin (an organic sulfur compound extracted from garlic), curcumin (a phenolic compound isolated from the rhizome of turmeric) and silymarin, can be used as telomerase inhibitors.
Allicin can inhibit telomerase activity in gastric cancer cells and induce apoptosis in gastric cancer SGC-7901 cells.
In addition, it was found that the main mechanism of curcumin inducing apoptosis of human leukemia cell line K-562 was through telomerase inhibition.
7: Indole-3-carbinol (I3C), a chemical substance in Cruciferae.
Indole-3-carbinol (I3C), a natural inhibitor, is a phytochemical in cruciferous vegetables and is used to target telomerase in prostate cancer cells.
A study found that I3C can significantly inhibit telomerase activity and expression of hTERT mRNA in prostate cancer cell lines, thus contributing to the treatment of prostate cancer.
In addition, it is found that telomerase is active in 85-95% of cancer cells, so telomerase is a good target for cancer treatment.

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