what is Topiramate API Powder?
Topiramate API Powder is a natural monosaccharide, dextrofructose sulfide, and is currently widely used as a broad-spectrum antiepileptic drug in clinical practice in China, along with Felbamate, lamotrigine, and Vigabatrin. It has also been used for alcohol dependence and essential tremor.For epilepsy, this includes treatment for generalized or focal seizures.
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Product name |
Topiramate API Powder |
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CAS |
97240-79-4 |
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Molecular formula |
C12H21NO8S | |
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Molecular weight |
339.36 | |
| EINECS | 619-263-3 | |
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Appearance |
white powder |
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| Melting point | 125°C | |
| Density | 1.336±0.06 g/cm3(Predicted) |
what is the history of Topiramate API Powder?
Topiramate was discovered in 1979 during their research work at Pharmaceuticals.Topiramate was first sold in 1996. A Pharmaceutical company was granted final approval by the FDA for the sale of generic topiramate in the United States and the generic version was made available in September 2006.The last patent for topiramate in the U.S. Topiramate API Powder was for use in children and expired on 28 February 2009.
What is the uses of Topiramate API Powder?
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Topiramate API Powder is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay. Topiramate API Powder is most frequently prescribed for the prevention of migraines,as it decreases the frequency of attacks.Topiramate is used to treat medication overuse headache and is recommended by the European Federation of Neurological Societies as one of the few medications showing effectiveness for this indication
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Topiramate API Powder One common off-label use for topiramate is in the treatment of bipolar disorder
it has been used as a treatment for alcoholism
Other uses include treatment of obesityand binge eating disorder,and off-setting weight gain induced by taking antipsychotic medications.
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Product Specification
| Items | Specifications |
Result |
|
Appearance |
A white or off-white powder |
white powder |
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Assay |
98.0% min |
99.2% |
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Identification |
Conforms to structure |
Conforms |
| Individual impurity | 0.1% max | 0.06% |
| Total impurities |
0.5%max |
0.3% |
| Water Determination | 0.5% max | 0.1% |
| Residue on ignition | 0.2% max | 0.05% |
| Optical Rotation | -28.6° to - 35.0° | -30.2° |
| Heavy metals | 10PPM | Conforms |
What are the pharmacological effects of Topiramate API Powder?
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The main mechanism of action of Topiramate API Powder is to block the spread of epileptic seizures rather than prevent their occurrence. 1. Blocking voltage dependent sodium channels to reduce the duration of epileptic discharges and the number of action potentials produced per discharge. |
Recent studies have shown that blocking L-type high-voltage dependent calcium ion channels may be one of the most important mechanisms of topiramate's antiepileptic effect
How and where to Topiramate API Powder?
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We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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