Quetiapine Fumarate Powder 99% Purity CAS 111974-72-2

Quetiapine Fumarate Powder 99% Purity ICI-204636 is dealing with mental illness. CAS number: 211073-09-1. At room temperature, it is a white or off-white crystalline powder. Molecular formula: C25H29N3O6S Molecular weight: 499.58; EINECS number 1308068-626-2.Hot sales Quetiapine hemifumarate is a new antipsychotic product, which is an antagonist of various neurotransmitter receptors in the brain. Its antipsychotic mechanism may be mainly through blocking the D2 receptor and 5-HT2 receptor of central dopamine. It also blocks histamine H1 and adrenalin a1 receptors, but has no affinity for muscarinic and benzodiazepine receptors.

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What are the pharmacodynamic characteristics of Quetiapine fumarate?

Quetiapine Fumarate Powder 99% Purity ICI-204636 is a non classical antipsychotic product that interacts with multiple neurotransmitter receptors. In the brain, quetiapine has a high affinity for 5-hydroxytryptamine (5HT2) receptors, which is greater than its affinity for dopamine D1 and dopamine D2 receptors in the brain. Quetiapine has high affinity for histamine receptors and adrenergic alpha 1 receptors, low affinity for adrenergic alpha 2 receptors, but little affinity for cholinergic toxin receptors or benzodiazepine receptors. The activity test of quetiapine against antipsychotic product showed a positive result in conditioned avoidance reflex.
In a multi dose clinical trial, it was found that there was no difference in prolactin levels between different doses of quetiapine groups, nor was there a difference between the placebo group. So, quetiapine do not produce persistent prolactin elevation.
In a trial comparing quetiapine with chlorpromazine and two trials comparing it with haloperidol, the short-term efficacy of quetiapine was comparable to that of the control product. According to clinical application data, quetiapine are effective in treating both positive and negative symptoms of schizophrenia.

Interaction between Quetiapine fumarate and other products?

1: The combination of Quetiapine Fumarate and lithium does not affect the pharmacokinetics of lithium and does not induce liver enzyme systems related to antipyrine metabolism. Clinical results have shown that the combination therapy of quetiapine fumarate and lithium carbonate has significant therapeutic effects on patients with manic episodes of bipolar disorder. It can not only significantly improve patients' clinical symptoms and some cognitive functions, but also has fewer adverse reactions, which is worthy of further promotion and application.
2: The combination of quetiapine and phenytoin can increase the clearance rate of quetiapine. If quetiapine is used in combination with phenytoin or other liver enzyme inducers (such as carbamazepine and rifampicin), the content of quetiapine should be increased to maintain the effect of antipsychotic symptoms. If phenytoin is discontinued and replaced with a non inducer (such as Sodium 2-propylpentanoate), the dosage of quetiapine needs to be reduced.
3: Combination with risperidone or haloperidol does not significantly alter the pharmacokinetics of quetiapine. However, the combination of quetiapine and sulfamethoxazole increases the clearance rate of quetiapine.
4：The main enzyme mediating metabolism in cytochrome P450 is CYP3A4. Caution should be exercised when combining quetiapine with ketoconazole or erythromycin.

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FAQ:

Q1:What conditions is Quetiapine fumarate mainly suitable for?
It is used for schizophrenia, bipolar disorder with manic/depressive episodes, and can also assist in improving severe insomnia and accompanying emotional problems characterized by restlessness.
Q2:What are the adverse reactions of Quetiapine fumarate?
In the early stage, patients may experience drowsiness, dizziness, weight gain, dry mouth, and orthostatic hypotension. Most of these symptoms will gradually subside as the duration of medication use increases.
Q3:What physical indicators should be monitored when using Quetiapine fumarate?

Regularly monitor blood sugar, blood lipids and thyroid function. Long-term use may affect metabolism, and the dosage should be evaluated by a doctor on a regular basis.   

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