Memantine Hcl Powder is a white crystalline substance used clinically to improve cognitive function and delay the progression of Alzheimer's disease. In addition, it is currently the only non competitive NMDA receptor antagonist, approved by CPMP and FDA for the treatment of moderate to severe Alzheimer's disease patients between 2002 and 2003, respectively. Clinical findings have shown that high-quality Memantine can inhibit the overactivation of NMDA receptors to reduce excitotoxicity, protect and repair healthy neurons, slow down neuronal cell apoptosis rate, while not affecting the physiological activation process of NMDA receptors required for cognition.
| Molecular formula |
|
|
|
Item |
Standard |
Test Results |
|
Appearance |
White powder |
Conforms |
|
Identification (IR) |
Concordant with reference spectrum |
Conforms |
|
Assay |
≥99.0% |
99.2% |
|
Water |
<2.0% |
0.4% |
|
Residual solvent |
<1.0% |
0.2% |
|
Heavy Metals |
≤15 |
10 |
|
Loss on Drying |
≤0.3% |
0.04% |
|
Residue on Ignition |
≤0.3% |
0.08% |
|
Chromatographic purity |
Meets the requirements |
Conforms |
|
Organic volatile impurities |
Meets the requirements |
Conforms |
|
Microbial assessment |
Compliance with indicators |
Conforms |
|
BSE |
not detected |
not detected |
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GMO |
not detected |
not detected |
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Allergen |
not detected |
not detected |
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Radiation |
not detected |
not detected |
|
Conclusion： |
Conform with enterprise specification . |
What is the pharmacological action of this product?
Alzheimer's disease is a progressive neurodegenerative disease. Currently, increasing evidence suggests that dysfunction of glutamatergic neurotransmitters, especially when NMDA receptor function is impaired, can manifest as clinical symptoms and disease progression of neurodegenerative dementia. MeMantine hydrochloride is a voltage dependent, moderately affinity non competitive NMDA receptor antagonist that can block neuronal damage caused by pathological elevation of glutamate concentration. In addition to Memantine Hcl Powder, cholinesterase inhibitors (such as: Donepezil,Rivastigmine,Galanthamine)
What's the new progress in the combined use of this product?
Memantine Hcl Powder, as a noncompetitive N-methyl-D-aspartic acid (NMDA) receptor antagonist, can uncompetitively block NMDA receptor and reduce the excessive excitement of NMDA receptor caused by glutamic acid. Therefore, the effects of levodopa, dopamine receptor agonist and anticholinergic drugs may be enhanced and the effects of barbiturates and nerve blockers may be weakened when NMDA antagonists are used together. In addition, because Menantine Hydrochloride and Amantadine 768-94-5 are NMDA antagonists in chemical structure, they should be avoided to avoid drug-induced psychosis.
The latest research shows that the use of hydrochloric acid diamond powder combined with other drugs for the treatment of moderate to severe AD patients will have better therapeutic effects.For example: Nimodipine 66085-59-4
Nimodipine is a dihydropyridine Ca2+ antagonist, which can act on nerve cells, cerebral vascular cells, and glial cells of the central nervous system, obviously dilating the diameters of cerebral vessels and meningeal vessels and delaying the cognitive decline of patients to a certain extent. When nimodipine is used in combination with Memantine Hcl Powder CAS 41100-52-1, the advantages of different pharmacological action links and action mechanisms can be complemented, resulting in a better curative effect.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Memantine Hcl Powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
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