Neu5Ac Powder CAS 131-48-6

Pure sialic acid is colorless and soluble in water, and it is also the most widely distributed substance in nature. It is mainly composed of glycoproteins, glycolipids or bacterial capsule substances in animal cell membranes or secretions. According to the research, it is found that the pure N-Acetylneuraminic acid does not undergo racemization in aqueous solution. Pure monoethylphthalein neuraminic acid and light monoethylphthalein neuraminic acid are very stable in aqueous solution. At 4℃, the storage of Neu5Ac powder will not change for several months.

What is N Acetylneuraminic acid?

N Acetylneuraminic acid is a carbohydrate widely existing in nature, and it is also the basic component of many glycoproteins, glycopeptides and glycolipids. It was originally isolated from jaw gland proteins, hence its name. In human body, the Neu5Ac powder content in brain is the highest, and the sialic acid content in cereal is 15 times that in liver, lung and other internal organs. Pure sialic acid has a wide range of biological functions, such as the regulation of half-life of blood protein, neutralization of various toxins, cell adhesion, immune antigen-antibody reaction and protection of cell lysis. Biochemical derivatives of sialic acid are also commonly used in drug synthesis.

What is the efficacy of sialic acid?

The magical effect of bird's nest lies in its high content of sialic acid (SA) compared to other nutritious foods. According to long-term scientific statistics, this product has the following benefits:

1, Improve infant intelligence and memory

In infants, the content of N-Acetylneuraminic acid is only 25% of that in breast milk, and a large amount of sialic acid is usually synthesized in the liver. In early childhood development, the brain develops rapidly, while the liver develops slowly, and the sialic acid synthesized by the liver is difficult to meet the needs of brain development. Research has found that increasing the content of sialic acid in the diet during lactation can increase the expression levels of learning related genes in infants, and their learning and memory abilities are significantly higher than those of their peers.

2,anti-senile dementia

Patients with early-stage dementia and schizophrenia have lower levels of sialic acid in their blood or brain compared to normal individuals.The study found that: Proteases located on the surface of nerve cell membranes may bind to sialic acid and can degraded by extracellular proteases. Researchers speculate that the content of sialic acid is highly correlated with the protection and stability of nerve fibers.

3,count-discrimination

The sialic acid at the end of the sugar chain can serve as a recognition site or mask recognition sites between molecules and cells, cells and cells, and cells and the outside world. The sialic acid connected to the end of the sugar complex through glycosidic bonds can effectively prevent some important antigen sites on the cell surface from being recognized and labeled, thereby protecting these sugar complexes from being recognized and degraded by the surrounding immune system.

4,Antibacterial, antiviral, anti-tumor
Due to the unique structure of the 9-carbon amino sugar in sialic acid molecules, there are no enzymes in the digestive system that degrade this substance. Therefore, the peptide complexes formed by it will not be degraded by enzymes in the digestive system and enter the intestine. In the intestine, specific sialic acid peptide conjugates can competitively bind with pathogenic bacteria, toxins, and viral particles entering the intestine, thereby preventing intestinal toxins, pathogenic bacteria, and viral particles from binding to intestinal mucosal cells. It can be inferred that adding sialic acid to food can enhance the antibacterial, detoxifying, and antiviral abilities of the intestine.

5,Inhibiting leukocyte adhesion and diminishing inflammation
When the tissue is inflamed or damaged, white blood cells gather around the inflamed tissue to play an antibacterial and anti-inflammatory role. In the 1990s, American scientists found that the aggregation of leukocytes was related to the cell adhesion process, and the cell adhesion process was related to the E- selection of an epidermal cell containing sialyltetrasaccharide nucleus on the surface of leukocytes. When inflammation occurs, endothelial cells are stimulated by cytokines to produce E-selection, which can recognize the tetrasaccharide on the surface of white blood cells and combine with it, so that white blood cells can adhere to vascular endothelium, and then reach inflammatory tissue through vascular endothelium. Therefore, the synthesis of sialic acid derivatives with simpler structure and more effective than tetrasaccharide as adhesion drugs to treat inflammation will become a research hotspot.

6,Enhance human immunity
Salivary acid is not degraded by digestive enzymes in the digestive system and can enter the intestine to prevent pathogenic microorganisms from adsorbing to intestinal cells, playing a role in resisting various pathogenic bacteria. The free sialic acid in body fluids can prevent the adsorption of cold viruses on cell surfaces, and based on this mechanism, anti cold drugs mainly composed of sialic acid derivatives have been developed.
7, Improve intestinal absorption of vitamins and minerals
Salivary acid carries a strong negative charge and is usually located at the end of glycoproteins or glycolipids on the surface of the cell membrane. It is the main source of negative charge on the cell membrane. The negative charge of sialic acid causes red blood cells and other cells to repel each other, avoiding meaningless cell interactions in the bloodstream. According to the principle of mutual attraction between opposite sexes, positively charged minerals and some vitamins (such as trace amounts of vitamin B12 in food) that enter the intestine are easily bound to highly negatively charged sialic acid. So, Neu5Ac powder can improve the absorption capacity of minerals and vitamins in the intestine, and supplementing sialic acid can enhance the body's absorption level of nutrients.

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