Estriol Powder CAS 50-27-1

Estriol Introduction

Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.

As a lean, professional supplier, we implement rigorous quality control to ensure batch stability and compliance. With an experienced international sales team, we offer highly competitive prices, reliable delivery times, and one-stop export services.

Our products are widely supplied to the pharmaceutical, health supplement, cosmetic, and feed industries in Europe, North America, Southeast Asia, and the Middle East.

Estriol Powder is a metabolite of estradiol and estrone. It is a white solid with the CAS number 50-27-1 and the molecular formula C18H24O3. Molecular weight: 288.38; EINECS number: 200-022-2Its value is very low in nonpregnancy and is mainly synthesized by the liver; During pregnancy, it is mainly synthesized by the fetal placenta. After synthesis, it is metabolized in the liver through maternal blood circulation and combined with sulfuric acid or glucuronic acid to form binding E3, which is discharged from urine. E3 plays an important role in regulating fetal intrauterine development and can affect the sensitivity of the pregnant uterus to oxytocin.

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Why does estriol cream have a better market prospect than other forms of estriol?

Estriol cream is an alternative medicine to estrogen. Ovestin cream is a hormone replacement therapy (HRT) that can be directly applied to the vagina to alleviate vaginal dryness and irritation caused by menopause this ointment can be used locally and has few side effects on the body. If there are some abnormal diseases caused by estrogen deficiency, this cream can be used for conditioning. For example, if there is atrophy in the lower part of the urogenital tract, this cream can be used for local external use before or after vaginal surgery in postmenopausal women, which can effectively promote the improvement of the condition. For some women with urinary incontinence, some relatively high doses can be used for maintenance treatment, so as to achieve better results. This can also effectively avoid excessive stimulation of estrogen to the endometrium, and the side effects of local medication are smaller than oral medication.

What is the clinical significance of Oestriol?

(1) monitoring of Estriol powder in diabetic pregnancies is helpful to understand the placental function and fetal development. The incidence of macrosomia in patients with diabetes mellitus increased by about 10 times that in nondiabetic patients, and increased E3 secretion in the placenta and increased E3 in serum or 24h urine. The incidence of stillbirth in diabetic pregnant women is much higher than that in non-diabetic pregnant women. Therefore, monitoring the change of E3 levels in blood and urine helps to determine the optimal delivery time for pregnant women with diabetes. In those with normal fetal development, E3 concentration gradually increased slowly in the second trimester of pregnancy and reached a peak at 41 ~ 42 weeks. It is generally believed that serum E3 should be greater than 31 nmol / L during a full-term pregnancy. If it is less than 6.9 nmol / L, the fetus dies in utero, and if it is > 6.9 nmol / L and < 13.9 nmol / L, the fetus is in critical condition. 24h urine < 10mg also indicates low fetal placental function.

(2) In the early stage of pregnancy-induced hypertension syndrome without fetal distress, E3 can remain normal due to the increase of uterine placental blood flow. In moderate and severe PIH, the activity of the renin-angiotensin-aldosterone system is enhanced, resulting in placental ischemia, and the serum E3 can be significantly decreased.

(3) The serum E3 of multiple pregnancies and overweight fetuses increased. Serum E3 decreased in overdue pregnancy, intrauterine growth retardation, fetal adrenal hypoplasia, and stillbirth.

What's the difference between estriol and estradiol?

Estriol powder and estradiol are two sex hormones mainly produced by women. Estradiol is a pregnancy hormone, which is found in large quantities only during pregnancy, while estriol is present in all women. The developing fetus and placenta naturally produce estriol hormone. If a woman wants to know whether she is pregnant, the home pregnancy test will look for the appropriate estriol content to see if a fetus is growing. Estriol is present in the blood and excreted in the urine, so a simple urine test or blood test can show whether a woman is pregnant. During pregnancy, female doctors occasionally check their estradiol levels to see if the pregnancy is going on normally. Estriol and estradiol can also be synthesized if women need hormone replacement therapy. Estriol levels were highest between the ages of 12 and 40. Estrogen levels soar during pregnancy and gradually decrease during menopause. If women have menopausal symptoms and difficulties, they can take some hormone supplements. Estradiol is also a sex hormone in premenopausal women. It is essential for sexual and reproductive health, but it can also affect other body organs, such as the skeletal system. It is very similar to estriol, but there are some differences. Estradiol is found in large numbers in young women who can still have children. On the other hand, estriol mainly comes from the fetus during pregnancy. Therefore, estriol levels were similar in postmenopausal women and young women who were not pregnant.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Estriol powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

FAQ:

Q1:Who should not use Estriol?
Strictly prohibited: Pregnancy or breastfeeding, unexplained vaginal bleeding, having or suspected of having estrogen-related cancers, having active thrombotic diseases or severe liver diseases, etc.
Q2:Is it safe to use Estriol? Is there any risk involved with long-term use?
The estriol vaginal preparation is a topical medication. The amount absorbed into the bloodstream is extremely low, so the risk is much lower than that of systemic hormone therapies such as oral administration.
Q3:What should be noted during the use of estriol?

Regular physical examinations and paying attention to abnormal signs: If there is new vaginal bleeding, spotting or severe discomfort, stop taking the medicine immediately and consult a doctor.

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