what is J 147 powder?
J 147 powder is a particularly effective neuroprotective agent with oral activity that can enhance cognitive ability. J-147 can pass through the blood-brain barrier (BBB). J-147 inhibits monoamine oxidase B (MAOB) and dopamine transporter, with EC50 values of 1.88 μ M and 0.649 μ M, respectively. J-147 has the potential for research on Alzheimer's disease (AD).
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Product name |
J 147 |
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CAS |
1146963-51-0 |
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Molecular formula |
C18H17F3N2O2 | |
| EINECS | 1592732-453-0 | |
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Molecular weight |
350.33 | |
| Boiling point | 412.8±55.0 °C(Predicted) | |
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Appearance |
white powder |
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| Density | 1.18±0.1 g/cm3(Predicted) |
What are the main uses of J 147 powder?
J 147 has the following purposes
- Alzheimer's disease research
J 147 is a multi-target small molecule compound targeting Alzheimer's disease (AD), and J-147 raw powder is mainly used for pathological mechanism research, drug screening, and potential treatment development of the disease.
- Neuroprotective effect
Experiments have shown that it may protect neurons by inhibiting neuroinflammation, reducing beta amyloid deposition, and improving mitochondrial function. The original powder can be used for related pharmacological experiments.
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As the active ingredient of candidate drugs, the raw powder can support research stages such as pharmacokinetics (PK/PD), toxicity assessment, and formulation development.
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Product Specification
| Items | Specification | Results |
| Appearance | White to off-white solid powder | Complies |
| Identification | Both NMR and MS data are consistent with those reported in the literature | Complies |
| Solubility | Soluble in DMSO | Complies |
| Assay (on the anhydrous basis) | 98.0%~102.0% | 99.3% |
| Conclusion：Conform with enterprise specification | ||
how J 147 powder works?
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J 147 powder acts as a neuroprotective and neurotrophic compound by inhibiting ATP5A, a key enzyme in the aging pathway. It also appears to enhance the production of brain-derived neurotrophic factor (BDNF), which helps neurons. Effects in animal models: Protects against neurotoxicity in cell cultures. Reduces levels of amyloid-beta peptides and increases BDNF in the hippocampus of mice. Enhances memory in rats. Prevents memory deficits in Alzheimer's-model mice. Shows potential for other conditions like traumatic brain injury. |
How to produce J 147 powder?
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Slowly add Trifluoroacetic anhydride (0.33mL, 2.36mmol) dropwise to a stirred solution of 1- (2,4-dimethylphenyl) -2- [(3-methoxyphenyl) methylene] hydrazide (500mg, 1.97mmol) and Triethylamine (0.33mL, 2.36mmol) in dichloromethane (5mL) at 0 ℃ and under nitrogen protection. The reaction mixture was stirred continuously at 0 ℃ for 1.5 hours. After the reaction was completed, the mixture was concentrated, and the residue was purified by column chromatography using a (1:10) mixture as the eluent to obtain the target product J 147 powder (571 mg, yield 83%). |
How and where to Buy J 147 powder?
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We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
Q: Are there any side effects of J 147?
A:The high bioavailability and blood-brain barrier penetration of J147 may also have contributed to its substantial therapeutic effect, Notably, no significant side-effects of J147 has been reported.
Q:What is the half life of J 147 powder?
A:(E/Z)-J147 Related Antibodies
The half life (t1/2) of (E/Z)-J147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).
Q: How was J 147 discovered?
A:J147 was developed in 2011. J147 is a modified version of a molecule (curcumin) found in the curry spice turmeric.
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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