Amantadine Hcl Powder CAS 665-66-7

The white crystalline Amantadine Hcl Powder is a symmetrical tricyclic amine that can inhibit virus penetration into host cells, affect virus shedding, inhibit its reproduction, and have therapeutic and preventive effects on viral infections. In addition, this product can also promote the synthesis and release of dopamine in the striatum, reduce the reuptake of dopamine by nerve cells, and counteract the effects of acetylcholine. It is also a major product used clinically to improve Parkinson's disease patients.

What are the latest studies on the antiviral effect of this product?

1-Adamantanamine hydrochloride has antiviral properties and belongs to a narrow spectrum class, which can be used to synthesize antiviral drug intermediates. However, this product can only be used to prevent and treat influenza caused by A2 virus. It is currently recognized as a product that can alleviate symptoms of type A influenza virus within 48 hours of onset. Clinical studies have found that this product can prevent RNA viruses from penetrating host cells. If the virus has already penetrated the host cell, it can prevent the virus from molting and releasing nucleic acid, interfering with the early replication of the virus. In addition, it can block virus channels on the host cell membrane, preventing the virus from entering human cells. In tissue culture, Amantadine Hcl Powder can prevent infection by myxovirus and paramyxovirus, and is also effective against in vitro parvovirus. However, in clinical applications, it only works against type A influenza virus and has no effect on type B influenza virus and parainfluenza virus. Although all the latest natural influenza A viruses are sensitive to AMantadine Hydrochloride, in tissue culture, it can be observed that virus strains exposed to Amantadine have resistance mutations, and the resistance mechanism is RNA mutation.

What other uses does this product have besides relieving senile dementia?

Amantadine Hcl Powder, as an anti-tremor paralysis product, can promote dopamine release. Although the mechanism of action is not clear, the release of dopamine in animal brain increased obviously after amantadine was used in animal experiments. Researchers speculate that this may be related to amantadine promoting the release of dopamine (DA) from dopaminergic nerve endings in striatum, strengthening the interaction between dopamine and catecholamine in the central nervous system and increasing the dopamine content of neurons. In clinical application, we found that amantadine can relieve all kinds of Parkinson's disease, and the curative effect is stronger than anticholinergic drugs but weaker than levodopa. It has obvious curative effect on primary tremor paralysis, encephalitis and tremor paralysis syndrome after cerebral arteriosclerosis, and can obviously relieve symptoms such as tremor and rigidity. If this product has a good antipyretic effect when combined with antibiotics, it can deal with various inflammations, septicemia, viral pneumonia, etc. During COVID-19, this product has become one of the treatment options.

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