Topiramate Introduction
Xi'an Faithful BioTech Co., Ltd. is an export-oriented biotechnology and chemical trading company headquartered in Xi'an, Shaanxi Province, China. Founded in 2018, the company focuses on providing pharmaceutical intermediates, plant extracts, food additives, and feed ingredients to the global B2B market.
Raw topiramate powder is a white crystalline powder with a bitter taste and is easily soluble in alkaline solutions. CAS：97240-79-4;Molecular formula: C12H21NO8S; Molecular weight: 339.36; EINECS: 619-263-3;The basic structure of this product is pyranose fructose aminosulfonate, which is different from other antiepileptic products. Topiramate also has multiple antiepileptic mechanisms, which can block voltage dependent sodium channels, enhance GABA activity at gamma aminobutyric acid A (GABAA) receptors, block glutamate AMPA receptor activity. In addition, this product also has a mild EC 4.2.1.1 inhibitor effect.
This product is primarily used for the treatment of epilepsy and the preventative treatment of migraines.
| Molecular formula |
|
|
|
Items |
Standard |
Result |
|
Appearance |
White to off-white powder |
White powder |
|
Solubility |
Freely soluble in dichloromethane |
Conform |
|
Identification |
Infrared absorption The retention time of the major peak of the sample solution corresponds to that of the standard solution, as obtained in the assay |
Conform Conform |
|
Related compounds |
Fructose ≤0.3% Compound A≤0.3% Individual unknown ≤0.1% Total impurities ≤0.5% |
Not detected 0.13% 0.08% 0.27% |
|
Residue on ignition |
≤0.2% |
0.07% |
|
Heavy metals |
≤10ppm |
Conform |
|
Specific rotation |
-28.6 -35.0 ,measured at 20 |
-31.1 |
|
Water |
≤0.5% |
0.16% |
|
Sulfamate and sulfate |
Sulfamate ≤0.1% Sulfate ion ≤0.1% |
Not detected Not detected |
|
Assay |
98.0～102.0%,calculated on anhydrous basis |
99.4% |
|
Residual solvent |
1,2-dichloroethane≤5ppm Pyridine ≤100ppm Ethanol ≤1000ppm MIBK≤1000ppm Acetone ≤1000ppm |
Not detected 12ppm 581ppm 13ppm 7ppm |
|
Conclusion |
Comply with USP38 specification. |
|
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What are the pharmacological effects of Topimax?
Topiramate has a diverse pharmacological mechanism of action and can be used to treat epilepsy and prevent migraines. It antagonizes excitatory L-Glutamic acid receptors, particularly the AMPA/kainate subtype, thereby reducing the transmission of excitatory signals. Secondly, it blocks voltage-sensitive channels, reducing abnormal high-frequency neuronal discharges; it also enhances the activity of the inhibitory neurotransmitter 4-Aminobutyric acid, resulting in a neurodepressant effect. Finally, Raw Topiramate Powder also acts on some calcium and potassium channels and has a slight interfering effect on EC 4.2.1.1. These multiple effects collectively constitute its pharmacological properties.
What are the side effects of topiramate?
The mechanism of action of Raw Topiramate Powder is mainly to enhance the inhibitory neurotransmitter gamma aminobutyric acid in the brain, thereby reducing neuronal overexcitation. For epilepsy patients, it can help control focal seizures, while for migraine patients, it can reduce the frequency and intensity of seizures. It should be noted that pyrazole esters may also cause serious side effects.
Due to the fact that TPM is often used in combination with other antiepileptic drugs, it is impossible to determine which drug or drugs are associated with adverse reactions. In placebo-controlled trials with rapid dose adjustment, the most common adverse reactions are symptoms related to the central nervous system, including ataxia, attention deficit, confusion, dizziness, fatigue, sensory abnormalities, drowsiness, and abnormal thinking; Less common adverse reactions include anxiety, forgetfulness, loss of appetite, aphasia, depression, diplopia, emotional instability, nausea, nystagmus, speech disorders, taste errors, visual abnormalities, and weight loss; Report on rare nephrolithiasis; There are individual reports of thromboembolism, and the correlation between it and drugs is unclear.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Raw topiramate powder etc. at a more favorable price. If you are interested, please leave a message.
We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.
FAQ:
Q1:What does Topiramate do for weight?
Topiramate can lead to weight loss, typically acting as an appetite suppressant and increasing satiety.
Q2: Is Topiramate a high risk product?
While Topiramate is very effective in preventing migraines and treating epilepsy, it also has many potential cognitive side effects and serious risks, so it has been classified as a high-risk product.
Q3:Who cannot take Topiramate?
This product is strictly prohibited for individuals with allergic reactions to this ingredient. Pregnant women should avoid using it.
Disclaimer: The information published on this website comes from the internet, which does not mean that this website agrees with its views or confirms the authenticity of the content. Please pay attention to distinguish it. In addition, the products provided by our company are only used for scientific research. We are not responsible for the consequences of any improper use.
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