What is Taurinamide HCl?
Taurinamide HCl is an organic compound derived from amino acids. It is a white to off-white crystalline powder and is the hydrochloride salt of an amide derivative of taurine. Taurine is widely distributed in animals and is one of the most abundant free amino acids in mammalian tissues, primarily found in the brain, heart, retina, and muscles. Taurinamide HCl, as an amidation product of taurine, can be prepared chemically using taurine as a starting material, or obtained from natural sources through derivatization. This compound is mainly used in scientific research, acting on neurotransmitter regulation, cell signal transduction, and other biochemical processes. It has broad application value in pharmaceutical synthesis, development of bioactive molecules, and chemical biology research.
How can taurinamide HCl be applied in biochemical and drug synthesis research?
Taurinamide HCl is primarily used in scientific research and experimental development in the life sciences and medicinal chemistry fields. In fundamental biochemical research, as an amide derivative of taurine, it is frequently used to study the metabolic pathways and physiological functions of taurine and its derivatives in vivo, including their potential regulatory roles in the nervous, cardiovascular, and immune systems. In medicinal synthesis, Taurinamide HCl serves as a key chemical intermediate for synthesizing novel biologically active compounds, providing a material basis for the discovery of innovative drug lead compounds. In in vitro experimental studies, this compound is used for bioactivity screening under cell culture conditions to assess its effects on specific cell lines or enzymatic targets. Furthermore, in analytical chemistry, it can be used as a reference standard or derivatization reagent in analytical methods such as high-performance liquid chromatography.
What is the antioxidant and antibacterial mechanism of Taurinamide HCl?
After entering the body, Taurinamide HCl is slowly hydrolyzed by amidases in the gastrointestinal tract, releasing free taurine at a uniform rate. Compared to direct taurine supplementation, it has a longer metabolic half-life, gradually increasing the concentration of taurine in the body and avoiding osmotic diarrhea caused by high doses. It relies on the sulfonamide group to chelate copper and iron ions, blocking the Fenton reaction of oxidative stress, reducing cellular lipid peroxidation damage, and achieving long-lasting organ antioxidant and nerve-soothing effects. As a synthetic intermediate, the amino site of the molecule can undergo alkylation and acylation modifications to derive trorotinidine derivatives with bactericidal and bacterial endotoxin-neutralizing activities. By disrupting bacterial cell walls and cross-linking lipopolysaccharides, it inhibits the proliferation of pathogenic bacteria. It can be developed alone as a metabolic modulatory preparation or used as a core building block in the synthesis of broad-spectrum anti-infective raw materials, covering both metabolic maintenance and antibacterial therapy pharmacological tracks.
MF of Taurinamide HCl
Molecular Formula: C2H9ClN2O2S
Molecular Weight: 160.62
Precision quality: 160.0077
Melting Point: 133℃
Boiling point: 315℃
Density: 1.38g/cm³
PH: 4.7～6.2
Product Specification
| Item | Specification | Result |
| Appearance | White crystalline powder | Complies |
| Identification | IR/HPLC consistent with standard | Complies |
| Assay | 98.5% ~ 101.5% | 99.74% |
| Purity | ≥ 99.0% | 99.39% |
| Loss on Drying | ≤0.8% | 0.36% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Heavy Metals | ≤ 10 ppm | < 5 ppm |
| Conclusion | Complies with enterprise standard | |
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FAQ：
Q1: What are the advantages of Taurinamide HCl as a taurine prodrug with its sustained-release metabolism?
A1: It slowly hydrolyzes in vivo to release taurine, resulting in stable and sustained blood drug concentrations, a prolonged metabolic cycle, significantly reduced gastrointestinal irritation, and uniform hydrolysis rates across batches, ensuring stable long-term therapeutic effects.
Q2: Does Taurinamide HCl meet the requirements for antibacterial drug production?
A2: With its primary amino and sulfonamide dual active sites, it readily undergoes modification reactions, making it a dedicated raw material for tonolidine synthesis. It boasts high reaction conversion rates and few byproducts.
Q3: Is the storage stability of Taurinamide HCl powder suitable for long-term stockpiling?
A3: The hydrochloride form is resistant to hydrolysis and does not readily absorb moisture. Dry, light-protected storage results in extremely low impurity growth. The powder has uniform flowability, making it suitable for long-term storage requirements in laboratory synthesis and industrial formulation processing.
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