Nooglutyl Introduction
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Nooglutyl is a new type of cognitive enhancer, which is a derivative of L-Glutamic acid. It is a small molecule compound with CAS number 112193-35-8; its molecular formula is C₁₁H₁₂N₂O₆ and its molecular weight is 268.22. Its EINECS number is 200-184-4. Nooglutyl Powder main application area lies in its effects on the central nervous system (CNS).
What is the mechanism of action of Nooglutyl?
Nooglutyl Powder belongs to a new type of neuroregulatory research organic compound. Its core action pathway is the positive regulation of AMPA receptors. The in vitro radioactive ligand binding test data can confirm that this substance can selectively bind to AMPA receptors and has a competitive inhibitory effect on the binding process of AMPA receptor-specific activating ligands. The half-inhibitory concentration IC50 is 6.4 μM, thereby enhancing the efficiency of neural signal transmission mediated by L-Glutamic acid.
The series of in-depth experiments show that the above regulatory effect is not achieved by changing the release amount of L-Glutamic acid, but by enhancing the sensitivity of the AMPA/KAINIC ACID receptors on the postsynaptic membrane to chemical signals; this process can activate calcium-dependent protein kinases and protein kinase C, and ultimately achieve an increase in synaptic signal transmission efficiency.
In addition, Nooglutyl does not interfere with the binding state of dopamine D2 receptors under in vitro detection conditions; however, when administered to intact living models, it can indirectly regulate dopamine-related signaling pathways, such as changing the dissociation constant of D2 receptors and the expression abundance of the receptors. Current research generally believes that this physiological change is indirectly mediated through the glutamate signaling pathway.
What is the use of Nooglutyl?
The Regulatory Effect On Neural Learning Signals
Nooglutyl can regulate the level of neural signal transmission in the body, optimizing the information acquisition and memory retention performance of experimental model individuals. Relevant experimental data indicate that it can alleviate abnormal neural signal responses caused by hypoxia and alcohol exposure during the embryonic stage, and at the same time improve the completion effect of conditioned reflex learning behaviors; for memory signal disorders caused by long-term interruption of exogenous substances, this sample also has obvious regulatory and improvement effects.
Related Characteristics Of Brain Tissue Protection And Injury Repair
The neuro-regulatory properties of Nooglutyl Powder are also reflected in the aspect of brain tissue protection. In vitro and in vivo experiments on various brain tissue injury models, covering scenarios such as intracranial hematoma and cerebral blood supply blockage, showed that after adding Nooglutyl, the range of damaged brain tissue was significantly reduced, and it could also alleviate the abnormal neural transmission and decline in limb coordination caused by the injury, possessing application research value related to brain tissue protection.
MF of Nooglutyl
| CAS | 112193-35-8 |
| Molecular formula | C11H12N2O6 |
| Molecular weight | 268.22 |
| EINECS | 200-184-4 |
| Density | 1.514±0.06 g/cm3 |
| Boiling point | 704.7±60.0 °C |
Specification
| Item | Specification | Result |
| Appearance | White powder | Complies |
| Identification | Complies | Complies |
| Water | <2.0% | 0.40% |
| Residual solvent | <1.0% | 0.20% |
| Loss on drying | <0.5% | 0.10% |
| Assay | ≥99.0% | 99.10% |
| Conclusion | Conform with enterprise specification | |
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| Transportation Time | Shipping method | Cargo weight requirements | Advantage |
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| 7-15 days | By Air | Suitable for more than 50kg. fast and cheaper for large order |
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| 15-60 days | By Sea | Suitable for more than 500kg. Cheapest shipping way |
Our strengths:
Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China,Our company can provide Nooglutyl Powder etc. at a more favorable price. If you are interested, please leave a message.
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FAQ:
Q1:Does Nooglutyl have any direct effect on the dopamine system?
Experiments conducted in vitro showed that it does not directly affect the dopamine D2 receptor. However, after administration in animals, an indirect effect on the D2 receptor was observed. It is speculated that this effect is mediated through the L-Glutamic acid neurotransmitter system.
Q2:What effects does nooglutil have on the system of L-Glutamic acid?
As a derivative of L-Glutamic acid, it enhances the function of AMPA receptors to strengthen the neurotransmission of L-Glutamic acid, improves synaptic efficiency, and thereby improves cognitive functions such as memory. The research suggests that this constitutes the basis of its cognitive-enhancing effect.
Q3:How is the development prospect of Nooglutyl?
Its future prospects are currently mainly limited to the field of basic research. However, as a positive regulator of AMPA receptors, it has demonstrated the potential to improve cognitive impairment and neuroprotection in animal experiments. The mechanism of action is clear, and it is a valuable tool compound in neuroscientific research.
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