Product description
Aprotinin can inhibit kalinase and trypsin and is a natural non-specific serine protease inhibitor. It is a single-chain basic protein composed of 58 amino acid residues, and there are three disulfide bonds in the chain that are cross-linked with each other. For a long time, Aprotinin has been used in the treatment of acute pancreatitis. After the 1990s, aprotinin began to be used in cardiopulmonary thoracic surgery to protect platelets, reduce bleeding and bleeding, and for the clinical treatment of patients with coagulation disorders. As a result, the market size of aprotinin expanded rapidly and it has leaped to become one of the important biochemical drugs.
Aprotinin is a small molecule that resists fibrinolysis and inhibits trypsin and related proteolytic enzymes. In cell biology, aprotinin is used as a protease inhibitor to prevent protein degradation during the lysis and homogenization of tissues and cells. Aprotinin inhibits fibrinolytic activity in a dose-dependent manner and prolongs the coagulation time simultaneously. In vitro, Aprotinin is an effective inhibitor of the endogenous coagulation pathway.
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COA
| ltems | Standard | Results |
| Description | A white powder or Pallide-flavens powder |
Conforms |
| Solubility | soluble in water and in isotonic solutions, practically insoluble in organic solvents |
Conforms |
| Identification | ||
| A.Thin-layer chromatography | Should meet the specification | Conforms |
| B.Trypsin inhibit activity | Should meet the specification | Conforms |
| PH | pH5.0～7.0 | 6.0 |
| Appearance of Solution | Clear | Clear |
| Absorption | Have the largest absorption at λ=277nm not more than 0.8 |
277nm 0.7 |
| Loss on drying | not more than 6.0% | 5.4% |
| Protein of higher molecular mass |
not more than 3.0% | 1.7% |
| Bacterial endotoxins | Less than 0.14 IU/Ph.Eu units of aprotinin |
Conforms |
| Abnormal toxity | Should meet the specification | Conforms |
| Histamine | Not more than 0.2 μg/3 Ph.Eur.U | Conforms |
| Activity | not less than 3.0EPU/mg on dry basis | 3.26EPU/mg (5868KIU/mg) |
| Conclusion | Conform with enterprise specification | |
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Stability
Aprotinin has dialyzability, and the pH value of the isoelectric point is 10 to 10.5. It is stable to high temperatures, acids and alkalis. When heated to 100℃ in dilute acid and placed at room temperature for 24 hours with pH=12.6, it remains very stable, but its activity decreases when pH=12.8. It can be digested by thermophilic proteases at 60-80℃ and is relatively stable to other enzymes. It is not an enzyme itself but a broad-spectrum inhibitor.
What is the drug aprotinin used for?
Aprotinin is a serine protease inhibitor with antithrombotic, antifibrinolytic, and antiinflammatory effects. It is effective in reducing bleeding and the need for blood transfusions after cardiac surgery with cardiopulmonary bypass.
What are the benefits of aprotinin?
Aprotinin is a nonspecific serine protease inhibitor that acts as an antifibrinolytic agent to prevent the breakdown of clots through the inactivation of plasmin, the preservation of platelet function, and the counteraction of dysregulated activity within the coagulation system.
What is the source of aprotinin?
Aprotinin is a single chain polypeptide isolated from bovine lung with antifibrinolytic and anti-inflammatory activities.
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Our Factory
Package
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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