99% Purity Kojic Acid Powder CAS 501-30-4

Kojic acid Introduction

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99% Purity Kojic Acid Powder is a specific inhibitor of melanin. CAS Number: 501-30-4 Molecular formula: C6H6O4 Molecular weight: 142.11, EINECS number: 207-922-4.It is an organic acid with antibacterial properties that is produced by the aerobic fermentation of glucose by Aspergillus candidus at a temperature range of 30 to 32 degrees Celsius. Its molecular structure is a substituted γ-pyrone. Among the γ-pyrone compounds existing in nature, the well-known ones are only Kojic acid and 3-Hydroxy-2-methyl-4H-pyran-4-one.After entering skin cells, it can complex with copper ions in cells, change the three-dimensional structure of tyrosinase, prevent the activation of tyrosinase, and inhibit the formation of melanin. Kojic acid whitening active agents have a better tyrosinase inhibitory effect than other whitening active agents. It does not act on other biological enzymes in the cell and has no toxic effect on the cell. At the same time, it can also enter the intercellular matrix to form intercellular glia, which plays a role in retaining water and increasing skin elasticity. At present, it has been added to various cosmetics to make whitening cosmetics for freckles, senile spots, pigmentation, and acne. Kojic acid also has the functions of scavenging free radicals, enhancing cell vitality, food preservation, and color protection. It is widely used in the field of medicine and food.

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Is kojic acid an organic acid?

Kojic acid is an organic acid with antibacterial properties that can be produced through fermentation of various substances by Aspergillus (a fungus). The industrialized 99% Purity Kojic Acid Powder is an organic acid produced by aerobic fermentation of glucose by Aspergillus and Candida at 30-32 ℃. Its molecular structure is a substituted gamma pyranone, and we know that the structure of pyranone is widely present in natural products. Coumarin is the most important compound containing an alpha pyranone structure. The Kojic acid, food additive maltol, flavonoids, and isoflavones in koji are all compounds containing a gamma pyranone structure. The only famous compounds among them are Kojic acid and maltol. Because Kojic acid and maltol are easy to produce and can serve as precursors for the production of other products, Kojic acid is widely used in food, medicine, agriculture, and other fields. Later, due to its excellent whitening effect and ability to lighten pigmentation, it was widely used in cosmetics.

What are the biochemical characteristics of Kojic acid?

Kojic acid crystals are prismatic, needle shaped, and colorless. 99% Purity Kojic Acid Powder is easily soluble in water, alcohol, and acetone, slightly soluble in ether, ethyl acetate, chloroform, and pyridine, but difficult to dissolve in most other solvents. It can be purified by crystallization in solvents such as acetone and ethyl acetate, or sublimated under reduced pressure at 150-200 ℃. There are literature reports that Kojic acid can enter skin cells and complex with copper ions in the cells, changing the three-dimensional structure of tyrosinase and preventing its activation, thereby inhibiting the formation of melanin. In addition, Kojic acid has certain antibacterial activity. Gram negative bacteria are more sensitive to Kojic acid than Gram positive bacteria, while most other antibacterial substances are the opposite. The antibacterial effect of Kojic acid is much lower than other antibacterial substances, and its antibacterial activity is antibacterial rather than bactericidal. And Kojic acid is ineffective against yeast, viruses, and bacteriophages. The reaction between Kojic acid and ferric chloride produces a special red color, and this method can be used to quantify Kojic acid.

How to obtain high-quality kojic acid?

There are several factors that affect the purification of this product, including: 1. Kojic acid can form insoluble metal chelates with divalent metal ions, which can be utilized during extraction; Although 99% Purity Kojic Acid Powder is soluble in water, its solubility is not high, and temperature has a significant impact on its solubility, which is beneficial for concentration, cooling, and crystallization; 3. Kojic acid is prone to react with iron elements, even when using stainless steel fermentation tanks. Kojic acid is unstable to light and heat, but this characteristic is closely related to pH value. Therefore, during fermentation, it is not only necessary to use special fermentation tanks made of inert metals, but also to control the temperature, light, and pH value of the fermentation environment. Extracting raw material Kojic Acid from fermentation broth is also quite difficult. In the 1970s, Beijing No.1 Daily Chemical Factory used the zinc salt method to completely solve this problem.

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FAQ:

Q1:How much kojic acid is typically added to cosmetics?
The recommended addition amount in cosmetics is usually 0.5% to 2.0%. A lower concentration (such as 20 μg/mL) can inhibit the activity of most TYROSINASE.
Q2:What are the side effects of kojic acid?
This component is relatively safe when used within the conventional addition concentration range in cosmetics. However, there has always been controversy regarding its safety assessment. Toxicological tests have confirmed that it has acute toxicity at high doses, and in vitro cell experiments have also revealed a risk of DNA damage.
Q3:What should be noted when using Kojic acid?

Kojic acid is unstable to light, heat and metal ions. Therefore, special attention should be paid during formulation and storage. It is necessary to avoid high temperatures and pay attention to the concentration. People with sensitive skin are advised to conduct a skin test before using it for the first time.  

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