What is Selexipag API?
Xi'an Faithful BioTech Co., Ltd., a high-tech export biotech company headquartered in Xi'an, delivers integrated services covering research & development, mass production and global distribution. We have over 10 years of experience in biomaterials and fine chemicals, with solid capabilities in technology research and manufacturing. Selexipag API (CAS: 475086-01-2, C₂₆H₃₂N₄O₄S) is a white to off-white crystalline powder. It is a highly selective prostacyclin receptor agonist. Thanks to its distinct molecular structure and targeted action, it is a leading active substance used for pulmonary hypertension. Reduced levels of prostacyclin and related synthase in the lungs lead to pulmonary hypertension, accompanied by aggravated pulmonary vasoconstriction and elevated pressure. Selexipag binds to prostacyclin receptors to simulate the function of natural prostacyclin. It relaxes pulmonary blood vessels, expands vascular passages, reduces pulmonary arterial pressure and improves blood flow.
Compared with similar products, Selexipag API has better structural stability, is non-hygroscopic and light-resistant. Its solid state stays stable at room temperature for a long period, ideal for long-term continuous use.
Selexipag Manufacturing Process
The industrial synthesis of Selexipag consists of five steps. Starting with heterocyclic raw materials, the process involves aminoalkylation, N-isopropylation, oxyalkylation, and hydrolysis of tert-butyl ester. Finally, the crude product is obtained by condensation with methanesulfonamide using carbodiimide catalysis. The finished product is obtained after multiple recrystallizations for purification. The process effectively suppresses impurity formation by optimizing the reaction system and temperature control. It is simple to operate, has easy-to-control solvent residues, and balances production costs and product quality.
COA
| Test Item | Specification | Result |
| Appearance | White powder | Conforms |
| Specification | 99% | Conforms |
| Odor | Characteristic | Conforms |
| Particle size | 100% pass 80 mesh | Conforms |
| Heavy metals | ||
| Total Heavy metals | ≤10ppm | Conforms |
| Microbial | ||
| Total microbacterial count | ≤1000cfu/g | Conforms |
| Yeast &Mould | ≤100cfu/g | Conforms |
| Escherichia Coli presence | Negative | Conforms |
| Salmonella | Negative | Conforms |
| Staphylococcus | Negative | Conforms |
| Conclusion | Conform with enterprise specification | |
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Density 1.2±0.1 g/cm3
Molecular Formula C26H32N4O4S
Molecular Weight 496.622
Exact Mass 496.214417
PSA 113.36000
LogP 4.56
InChIKey QXWZQTURMXZVHJ-UHFFFAOYSA-N
Mechanism of action of Selexipag
Target Action: A selective prostacyclin receptor (IP receptor) agonist that selectively binds to and activates IP receptors in blood vessels.
Vasodilation: Dilates pulmonary and systemic resistance vessels, reducing pulmonary vascular pressure and pulmonary vascular resistance, and alleviating right ventricular load.
Inhibition of Proliferation/Remodeling: Inhibits abnormal proliferation of pulmonary vascular smooth muscle cells, delays pulmonary vascular remodeling, and prevents the progression of pulmonary hypertension.
Improved Blood Flow: Increases cardiac output and pulmonary blood flow, improving exercise tolerance and systemic perfusion.
Long-lasting Advantage: Metabolites also possess IP agonist activity, resulting in a sustained and stable vasodilatory effect.
why choose us
We adhere to the principle of "customer first, honesty first", and always provide customers with high-quality and efficient products and high-quality services. Choose faithfulness. Choose a healthy life!
With our continuous efforts and good service, we sincerely hope to establish long-term cooperation and common development with customers and give us a chance. We believe that we will satisfy you with first-class quality, safe and fast delivery and enthusiastic after-sales service.
Our Factory
Package
Shipping Methods
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
FAQ
01. What is the primary target of Selexipag?
It acts on the highly selective prostacyclin IP receptor, making it an IP receptor agonist.
02. What are the most common adverse reactions of Selexipag?
Headache, diarrhea, nausea, musculoskeletal pain, flushing, arthralgia, etc., mostly related to its vasodilatory effects.
03. Which organ primarily metabolizes and excretes Selexipag?
Selexipag API is primarily metabolized in the liver, with most metabolic products excreted through the kidneys.
Click email：Sales4@Faithfulbio.Com Or WhatsApp：+86 17782784907
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