What is SB 242084 dihydrochloride?
SB 242084 dihydrochloride is a 5-HT2C receptor antagonist with selectivity, competitiveness, and high affinity (pKi=9.0), which can penetrate the blood-brain barrier. It exhibits 158 fold and 100 fold selectivity towards 5-HT2A and 5-HT2B receptors in vitro, respectively, and can increase basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the nucleus accumbens in vivo. It may also enhance mitochondrial gene expression and oxidative metabolism through 5-HT2A receptors. This product has good research potential in negative symptoms of anxiety, depression, and schizophrenia, as well as acute organ damage.
It should be noted that this product is not sold to individuals and is only used for scientific research. It is not intended for any human experiments or non scientific animal experiments.
| Product name | SB 242084 dihydrochloride |
| CAS | 1049747-87-6 |
| Molecular formula | C21H21Cl3N4O2 |
| Molecular weight | 467.77604 |
| EINECS Number | NA |
| melting point | NA |
| solubility | NA |
| Storage conditions | Sealed in dry,Room Temperature |
| Appearance | white powder |
| boiling point | NA |
| Density | NA |
How is SB 242084 dihydrochloride produce?
The production method of SB 242084 dihydrochloride is as follows:
Synthesis method one: Add 25ml of DCM under nitrogen to a flame dried round bottom flask. After 3 hours, monitor the reaction mixture using thin-layer chromatography until the raw materials are completely consumed. Add diluted chemical substance (10ml, 0.1M) to the mixture.
It should be noted that this information may not be complete, and the actual production process may involve more steps and conditions. When producing chemical substances, safety regulations and laws should be strictly followed.
Product Specification
| Item | Specification | Results |
| Purity | ≥99% | 99.75% |
| Appearance | White powder | Complies |
| Color | Complies | Complies |
| Odor &Taste | Characteristic | Complies |
| Identification | Positive | Complies |
| Loss on Drying | ≤1.0% | 0.22% |
| Residue on ignition | ≤0.5% | 0.14% |
| Conclusion | Conform with enterprise specification | |
Where is SB 242084 dihydrochloride usually used?
SB 242084 dihydrochloride is a selective, competitive, and high affinity 5-HT2C receptor antagonist with the following research applications:
Neuroscience research: It can increase the basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and the release of dopamine in the nucleus accumbens. Therefore, it has practical value in studying the basal activity and dopamine release of dopaminergic neurons.
Research on mitochondrial gene expression and oxidative metabolism: It can increase mitochondrial gene expression and oxidative metabolism through 5-HT2A receptors, thus having potential applications in related studies.
Research on mental illness: It has good research potential in negative symptoms of anxiety, depression, and schizophrenia, as well as acute organ damage.
In summary, it is mainly applied in neuroscience, mitochondrial gene expression and oxidative metabolism research, as well as research on mental disorders.
What are the effects of SB 242084 dihydrochloride?
SB 242084 dihydrochloride has the following effects:
Pharmacological action: It is a selective, competitive, and high affinity 5-HT2C receptor antagonist that can penetrate the blood-brain barrier. It can increase the basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and the release of dopamine in the nucleus accumbens. In addition, it can also increase mitochondrial gene expression and oxidative metabolism through 5-HT2A receptors.
Research potential: It has good research potential in negative symptoms of anxiety, depression, and schizophrenia, as well as acute organ damage.
Please note that this product is for scientific research purposes only and cannot be used for medicine, clinical diagnosis or treatment, food, cosmetics, and other purposes. Please wear laboratory clothes and disposable gloves and masks during operation to ensure safety and health.
How and where to buy SB 242084 dihydrochloride wholesale?
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You can trust our order because we have a good record of selling legal educational drugs.
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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