What is Flurbiprofen?
Flurbiprofen is an effective non-steroidal anti-inflammatory compound with oral activity, which has antipyretic and analgesic activities and is often used in the study of inflammatory diseases. Flurbiprofen is a non-selective cyclooxygenase (COX) inhibitor, which can be used in the study of colon cancer.
Flurbiprofen is a non-selective cyclooxygenase inhibitor, which can inhibit the synthesis of prostaglandin, thus achieving anti-inflammatory, antipyretic and analgesic effects.
Flurbiprofen powder is a white fine crystalline powder. Melting point is 110111℃. Soluble in methanol, ethanol, ether, acetone, chlorine, chloroform and other organic solvents, soluble in acetonitrile, almost insoluble in water, with irritating odor.
| Product name | Flurbiprofen |
| CAS | 5104-49-4 |
| Molecular formula | C15H13FO2 |
| Molecular weight | 244.27 |
| EINECS Number | 225-827-6 |
| Storage condition | Sealed in dry,Room Temperature |
| Melting point | 110-112 °C(lit.) |
| Solubility | Soluble in methanol: 50mg/mL |
| Appearance | White to off-white powder |
| Boiling point | 376.2±30.0 °C(Predicted) |
| Density | 1.1795 (estimate) |
How does flurbiprofen work?
Flurbiprofen is an aryl propionic acid nonsteroidal anti-inflammatory drug, which has analgesic, anti-inflammatory and antipyretic effects by inhibiting prostaglandin synthase. The anti-inflammatory effect and analgesic effect are 250 times and 50 times that of aspirin, respectively, which is stronger than ibuprofen, and the toxicity is lower. It is one of the strongest propionic acid nonsteroidal anti-inflammatory drugs.
Flurbiprofen also slightly inhibits platelet adhesion and aggregation, so it may induce bleeding. Flurbiprofen is well tolerated, so those who are ineffective or intolerant of aspirin can choose flurbiprofen.
Product Specification
| Item | Specification | Results |
| Appearance | White or off-white powder | Off-white powder |
| Identification | By HPLC | Complies |
| Melting Point | 120ºC~130ºC | 126ºC |
| Loss on Drying | ≤1.00% | 0.21% |
| Heavy Metals | ≤ 10ppm | Complies |
| Sulfated Ash | ≤ 0.10% | 0.03% |
| Chlorine Content | 17.5%~19.5% | 19.30% |
| Arsenic Content | ≤ 0.1ppm | 0.09ppm |
| Lead VContent | ≤ 3.0ppm | 0.50ppm |
| Cadmium Content | ≤ 0.1ppm | 0.10ppm |
| Mercury Content | ≤ 0.1ppm | 0.10ppm |
| Microbiological Test | Coliforms:Negative | Negative |
| Salmonella: Negative | Complies | |
| Total plate count: ≤1000 CFU/g | Pass | |
| Yeast&Mold: ≤50 CFU/g | Pass | |
| Related Substances | Impurity A: ≤0.30% | 0.18% |
| Other unknown impurity: ≤0.10% | 0.07% | |
| Total Impurities: ≤0.50% | 0.42% | |
| Assay | ≥ 98.0% | 99.50% |
| Conclusion | Conform USP Standard. | |
What are the functions of flurbiprofen?
1, antipyretic
Flurbiprofen can inhibit the synthesis of prostaglandin by inhibiting cyclooxygenase, thus achieving antipyretic effect.
2. Analgesia
Flurbiprofen powder can achieve analgesic effect by inhibiting the synthesis of prostaglandin.
3. Anti-inflammatory
Flurbiprofen can achieve anti-inflammatory effect by inhibiting the synthesis of inflammatory factors.
4. Anti-rheumatism
Flurbiprofen can achieve anti-rheumatic effect by inhibiting the synthesis of arachidonic acid.
5. Anti-infection
Flurbiprofen also has certain anti-infection effect. It mainly inhibits the cell wall synthesis of bacteria, so that the cell wall of bacteria is defective, thus achieving the effect of anti-infection.
HTML5 atlas of Flurbiprofen
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Does Flurbiprofen have anti-inflammatory and analgesic effects?
Flurbiprofen powder is a potent antipyretic, anti-inflammatory and analgesic drug of phenylpropionic acid, which can inhibit prostaglandin from synthesizing cyclooxygenase and have analgesic, anti-inflammatory and antipyretic effects. Its anti-inflammatory and analgesic effects are 250 times and 50 times that of acetylsalicylic acid, respectively. It is metabolized into hydroxy flurbiprofen and its aldehyde-acid conjugate in the liver. T1/2 is 3.5h. Excretion by urine and feces is about 60% and 40% respectively. Age has no obvious effect on drug metabolism. Mainly used for rheumatoid arthritis, rheumatoid arthritis, ankylosing spondylitis and degenerative arthritis. It can also prevent aphakic cystic punctate edema after surgical lens removal, inhibit pupil contraction during surgery, treat cataracts and eye inflammation after trabeculoplasty argon laser surgery.
What are the differences between flurbiprofen and ibuprofen?
1, the chemical composition is different
Although flurbiprofen and ibuprofen are both non-steroidal anti-inflammatory drugs, their main components are different. Flurbiprofen is mainly composed of flurbiprofen powder, while ibuprofen is mainly composed of ibuprofen powder.
2. Different indications
Flurbiprofen: It is mainly used for postoperative pain and post-traumatic pain. Ibuprofen: It is mainly used for fever caused by nonspecific or specific cold, as well as headache and toothache.
3. Different taboos
The taboo groups of the two are different. Flurbiprofen: It is forbidden for people under 18 years old. After taking aspirin or other non-steroidal anti-inflammatory drugs, it is forbidden for people with asthma and allergic history of non-steroidal anti-inflammatory drugs. Ibuprofen: it is forbidden for people who are allergic to ibuprofen, and it is forbidden for those who have allergic symptoms after using ibuprofen.
What are the precautions of flurbiprofen?
1. People with a history of gastrointestinal ulcer should use it with caution.
2. Patients with a history of bronchial asthma or patients with bronchospasm due to taking other non-steroidal anti-inflammatory drugs should be used with caution.
3. Patients with heart, liver and kidney dysfunction, hypertension and hemophilia should use it with caution.
4. Long-term use should regularly check the patient's blood routine, liver function and renal function.
5. Flurbiprofen powder can cause vision changes, so patients with endophthalmopathy should use it with caution.
6. She can inhibit platelet aggregation and prolong bleeding time, so patients with prolonged bleeding time should use it with caution.
How and where to buy Flurbiprofen Powder wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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