What is Pantoprazole Sodium?
Pantoprazole Sodium is an H+,K+-ATPase inhibitor, which can inhibit gastric acid secretion stimulated by histamine, gastrin, acetylcholine and other factors. It is used to treat diseases related to gastric acid secretion disorder, with the advantages of high cure rate, quick onset and less adverse reactions.
Pantoprazole soda powder is a white to off-white powder.
Pantoprazole sodium is one of several common proton pump inhibitors (PPI) in the market at present. According to literature reports, the bioavailability of pantoprazole is 7 times higher than that of omeprazole, and its selectivity to parietal cells is more specific.
| Product name | Pantoprazole Sodium |
| CAS | 138786-67-1 |
| Molecular formula | C16H14F2N3NaO4S |
| Molecular weight | 405.35 |
| EINECS Number | 604-093-4 |
| Storage condition | Inert atmosphere,Store in freezer, under -20°C |
| Melting point | 199-202°C |
| Solubility | Soluble in DMSO (slight), methanol (slight, ultrasonic treatment) and water (slight) |
| Appearance | White to off-white powder |
| Boiling point | 586.9°C at 760 mmHg |
| Stability | hygroscopicity |
What is the pharmacological mechanism of Pantoprazole Sodium?
Pantoprazole Sodium is a proton pump inhibitor for gastric parietal cells. It is relatively stable under neutral and weakly acidic conditions and rapidly activated under strongly acidic conditions. Its pH-dependent activation characteristics make it more selective for H+ and K+-ATPase. Pantoprazole Sodium can specifically inhibit the H+ and K+-ATPase on the secretory microtubules and tubular vesicles in the cytoplasm of the apical membrane of parietal cells, causing irreversible inhibition of the enzyme, thereby effectively inhibiting gastric acid secretion. Since H+ and K+-ATPase are the last process of acid secretion in parietal cells, this product has a strong acid inhibition ability.
Pantoprazole Sodium powder can not only non-competitively inhibit gastric acid secretion caused by gastrin, histamine, and choline, but also inhibit some basal gastric acid secretion that is not affected by choline or H2 receptor blockers. When used with other products, EUPANTOL has the advantage of small drug interactions. PANTECTA is metabolized by the I system of the cytochrome P450 enzyme system in hepatocytes, and can also be metabolized by the II system. When used with other drugs that are metabolized by the P450 enzyme system, the metabolic pathway of Pantoprazole Sodium can be carried out through the II enzyme system, which makes it less likely to have competitive effects on drug-metabolizing enzyme systems and reduce drug interactions in the body. It has no mutagenic, carcinogenic, or teratogenic effects.
Product Specification
| Item | Specification | Results |
| Appearance | Of-white to White Powder | Complies |
| Rotation from | -0.4°to+0.4° | Complies |
| Alkalinity pH value | 9.5~11.0 | 9.6~10.9 |
| Related substance | Individual impurity:NMT0.2% | 0.06% |
| Total impurities:NMT0.5% | 0.13% | |
| Moisture | 4.0%~6.0% | 5.0% |
| Heavy meta | NMT 20ppm | NMT 20ppm |
| Assay | NLT 98.0% | 99.35% |
| Concusion: | Conform with enterprise specification. | |
What does Pantoprazole Sodium adapt to?
1. Peptic ulcer bleeding.
2. Acute gastric mucosal injury caused by non-steroidal anti-inflammatory drugs and the occurrence of ulcer bleeding under stress;
3. Prevent gastric acid reflux complicated with aspiration pneumonia after general anesthesia or major surgery and in patients with debilitating coma.
4. Antiacid drugs and anti-ulcer drugs are used to treat acute upper gastrointestinal bleeding such as gastric and duodenal ulcer, acute gastric mucosal lesion of gastric ulcer and compound gastric ulcer.
HTML5 atlas of Pantoprazole Sodium
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What are the advantages of Pantoprazole Sodium?
1. Accurate site of action: Pantoprazole Sodium only binds to the active 5 and 6 fragments on the proton pump with high specificity, while omeprazole also binds to the inactive 7 and 8 fragments, and lansoprazole also binds to the inactive 7, 8 and 3 fragments.
2. Few drug interactions: Pantoprazole Sodium does not affect the activity of the P450 enzyme system of liver cells.
3. There is no significant difference in the healing rate of duodenal ulcer and gastric ulcer treated with Pantoprazole Sodium and omeprazole, and Pantoprazole Sodium is better tolerated.
4. Pantoprazole Sodium powder has no difference in efficacy with omeprazole in treating upper gastrointestinal bleeding caused by gastric mucosal lesions caused by various reasons, and has mild adverse reactions. It is one of the safe and reliable drugs for treating upper gastrointestinal bleeding.
Description of the external absorption of Pantoprazole sodium:
Pantoprazole sodium has the chemical structure of sulfenylbenzimidazole, and its stability is easily affected by many factors such as light, heavy metal ions, oxidizing and reducing components. Especially under acidic conditions, the chemical structure of Pantoprazole sodium can undergo destructive changes, resulting in discoloration and polymerization. Therefore, Pantoprazole sodium is unstable in acidic diluents, which can easily lead to wavelength shift during ultraviolet identification. Using water as a solvent: ① Using purified water as a solvent: The ultraviolet absorption result without acidity adjustment (pH=6.47) does not meet the standard requirements. After acidity adjustment (pH=6.85), the ultraviolet absorption result meets the standard requirements, and it is not appropriate to use purified water as a solvent. ② Using sterile water for injection as a solvent: (pH=6.83) The ultraviolet absorption result meets the standard requirements, but since the qualified acidity range of sterile water for injection is pH5.0-7.0. Therefore, it is not appropriate to use sterile water for injection as a solvent. ③ Using anhydrous ethanol as solvent: Referring to the quality standard identification method of the raw material drug, anhydrous ethanol was used as the solvent, and relatively satisfactory results were obtained. ．
In summary, the wavelength shift in the ultraviolet identification of Pantoprazole sodium is closely related to the pH of the diluent. The ultraviolet absorption detection using sterile water for injection and anhydrous ethanol as diluents has achieved relatively satisfactory results. Considering that the pH in the quality standard of sterile water for injection is 5-7, it is a better solution to use anhydrous ethanol as a diluent during ultraviolet identification, which is an ideal method for ultraviolet identification of Pantoprazole sodium for injection.
What is the difference between Pantoprazole sodium and omeprazole?
Pantoprazole sodium powder and omeprazole powder are both proton pump inhibitors that can inhibit gastric acid secretion.
Their main differences are:
1. Different chemical structures and acid suppression effects. Omeprazole is a first-generation proton pump inhibitor. Pantoprazole sodium is a structurally modified version of omeprazole, which has a better acid suppression effect and a longer duration.
2. Different stability. Under acidic conditions, Pantoprazole sodium is more stable than omeprazole.
3. Different drug interactions. Omeprazole has more drug interactions, while Pantoprazole sodium has a weaker inhibitory effect on liver enzymes, has less drug interactions, and is safer.
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