what is Rebamipide powder?
With the widespread use of proton pump inhibitors (PPIs) and the eradication of Helicobacter pylori infection as the main treatment for gastric ulcers, the clinical healing rate of peptic ulcers can reach up to 80% to 90%. However, the problem of ulcer recurrence still needs to be urgently addressed. In recent years, the relationship between ulcer healing quality and ulcer recurrence has been increasingly valued. Rebamipide powder, also known as Rebamipide, is a new type of anti ulcer drug that was first launched in Japan in 1990 as a drug for gastric ulcers and acute and chronic gastritis. Rebamipide is a gastric mucosal protectant that can increase gastric mucosal blood flow, synthesis of prostaglandin E2, and secretion of gastric mucus, promote the expression of epidermal growth factor and its receptors, and have the effect of preventing ulcer occurrence and promoting ulcer healing. Research has shown that it is effective in treating various experimental gastric ulcers, promoting the production of prostaglandins in the gastric mucosa, protecting the gastric mucosa from various ulcer causing factors, and is suitable for treating gastric ulcers, acute gastritis, acute exacerbation of chronic gastritis, and gastric mucosal lesions. It has high clinical application value.
 |
Product name |
Rebamipide |
|
CAS |
90098-04-7 |
|
|
Molecular formula |
C19H15ClN2O4 | |
|
Molecular weight |
370.79 | |
|
EINECS Number |
1308068-626-2 | |
|
Storage condition |
Sealed in dry,Room Temperature | |
|
Appearance |
white powder |
|
|
Melting point |
288-290°C dec | |
| Density | 1.394±0.06 g/cm3(Predicted) |
What are the pharmacological effects of Rebamipide powder?
The chemical structure of Rebamipide powder contains amide groups at the benzyl position and double bonds at positions 3 and 4 with carbonyl groups at position 2. It can dose dependently inhibit the activation of neutrophils to produce reactive oxygen species and effectively scavenge free radicals, thereby preventing damage to the gastric mucosa caused by free radicals.This product can also promote the synthesis of prostaglandins in the gastric mucosa and enhance the gastric mucosal barrier.In addition, this product inhibits the damaging effect of Helicobacter pylori (Hp) on gastric mucosa by preventing Hp from adhering to gastric epithelial cells, reducing oxidative stress, and lowering the concentration of cytokines produced by Hp. Animal experiments have shown that Rebamipide can clear free radicals in mucosal epithelial cells, significantly inhibit O2- production by neutrophils, and inhibit hydroxyl radicals? OH also has a clearing effect and can inhibit the production of Hp and chemokines. It can increase the synthesis of prostaglandins by inhibiting the damaging effect of bile acids on gastric mucosa.
What diseases is Rebamipide powder suitable for?
(1) The prevention and treatment of gastric mucosal damage caused by NSAIDs. Rebamipide has a significant reversal effect on the side effects of NSAIDs, such as reduced prostaglandin production and increased mucosal permeability in the gastric mucosa.(3) Other studies have reported that gastric cancer patients who took Rebamipide before surgery had significantly lower body temperature and serum IL-6 levels three days after surgery compared to the control group, indicating that rabeprazole has a certain improvement effect on postoperative systemic inflammatory response syndrome in gastric cancer surgery patients;Rebamipide may become a new approach for treating ulcerative colitis; It may become a new and effective treatment drug for Meniere's disease.if you need it,you can click email：sales1@faithfulbio.com
Product Specification
|
Test |
Specification |
Result |
|
|
Appearance |
A white or yellowish-white crystalline powder |
Complies |
|
|
Purity (HPLC) |
> 99.0% |
99.6% |
|
|
Melting Point |
286 - 294 ºC |
289 - 291 ºC |
|
|
Residue on Ignition |
≤ 0.2% |
0.1% |
|
|
Heavy Metals |
≤ 10 ppm |
Complies |
|
|
Loss on Drying |
≤ 3.0% |
1.4% |
|
|
Related Substances |
≤ 0.5% |
0.4% |
How to produce Rebamipide powder?
4-bromomethylquinolone and diethyl acetamidomalonate synthetic intermediate (R,S)-2-amino-3 -[2(1 H )-quinolone-4]propionic acid, and then condensed with p-chlorobenzoyl chloride to prepare rebamipide; wherein diethyl acetamidomalonate is prepared by oximation, reduction and acetylation of diethyl malonate , 4-bromomethylquinolone is prepared by condensation reaction of aniline and acetoacetyl chloride, bromination, and cyclization,Finally obtained Rebamipide powder.
How and where to buy Rebamipide powder wholesale?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
Send your Inquiry for more information, Click email：sales1@faithfulbio.comNow.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
Disclaimer: The articles on this website are mainly used for scientific research and academic exchange. Please carefully discern the authenticity of their viewpoints and content. If you discover any infringement. Please contact the administrator promptly. We are not responsible for the consequences of the information and services provided on this website.
Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
Send your Inquiry for more details, Click email：sales1@faithfulbio.com Now.
Hot Tags: rebamipide powder cas 90098-04-7, China, suppliers, manufacturers, factory, customized, wholesale, buy, price, bulk, pure, producer, discount, for sale, in stock, free sample, raw powder, raw material, made in China