Clemastine Fumarate Powder CAS 14976-57-9
Product Name:Clemastine fumarate powder
CAS NO.:14976-57-9
Molecular Formula:C25H30ClNO5
EINECS.NO:239-055-2
Synonym:clemastine fumarate;clemastine hydrogen fumarate;Clemastine (fumarate);
Meclastine fumarate;Clemastine fumarate salt;Mecloprodine
MOQ & Package:10g,100g,1kg etc Sub-package
Certificate:FDA,ISO,COA, HPLC, MSDS,TDS etc
Lead Time:1-3 days
Shipping:DHL,Germany DHL,Germany DPD,UPS,USPS,FedEx,EMS,By Air,By Sea etc
Store & Shelf life:Cool & dry place;36 months
Other:There are warehouses in the United States, Australia and Germany.
Description
what is Clemastine fumarate powder?
Clemastine fumarate powder is a potent, long-lasting, fast acting, and highly selective histamine H1 receptor antagonist that blocks H1 receptors and antagonizes cell toxicity. It is mainly used clinically for allergic diseases such as allergic skin diseases and allergic rhinitis, bringing good news to patients who have suffered from allergic diseases for years. Stine class drugs are potent, long-acting, and highly selective histamine H1 receptor blockers that have no inhibitory effect on cholinergic receptors in the central nervous system, and have no sedative or sedative effects. They are commonly used for allergic rhinitis, anti allergic asthma, urticaria, eczema, dermatitis, and pruritus. In recent years, "Stine" drugs have received increasing attention in local administration, and have been developed as nasal and ophthalmic topical drugs, thus becoming a class of non hormonal drugs for the treatment of allergic rhinitis.
 |
Product name |
Clemastine fumarate |
|
CAS |
14976-57-9 |
|
|
Molecular formula |
C25H30ClNO5 | |
|
Molecular weight |
459.96 | |
|
EINECS Number |
239-055-2 | |
|
Storage condition |
2-8°C | |
|
Appearance |
white powder |
|
|
Melting point |
158-162°C | |
| Density | 1.0247 (rough estimate) |
How Clemastine fumarate powder works?
Clemastine Fumarate is an oral antihistamine that works by promoting the development of myelin-making cells, called oligodendrocytes. Studies have also shown clemastine's effects in suppressing the immune system of mice and people without MS. Clemastine is an over the counter allergy medication, however, doses used in the MS clinical trial exceed the daily maximum recommendation.
clemastine regulates CHRM1, p38 MAPK, ERK, mTOR, and Wnt/β-catenin signaling pathways in OPCs, OLs, microglia, and neurons. The underlying mechanisms of action of clemastine are generally associated with promoting oligodendrocytes differentiation and maturation, inhibiting microglia induced neuroinflammation, and decreasing the apoptosis of neurons
What are uses of Clemastine fumarate powder?
Clemastine fumarate powder is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, watery eyes, itchy eyes/nose/throat/skin, cough, runny nose, and sneezing. This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose.Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Do not give other cough-and-cold medication that might contain the same or similar ingredients.
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Product Specification
|
Items |
Specifications |
Results |
|
Appearance |
White or almost white crystalline powder |
White crystalline powder |
|
Solubility |
Slightly soluble in methanol, very slightly soluble in water or trichloromethane |
Conforms |
|
Specific rotation |
+15°～+18° |
+16.3° |
|
Identification |
The location of the test aticle's principal spot is same as the 2Treference2T 2Tsubstance2T |
The location is same |
|
0TThe infra-red reference spectra of test article confirms with the 0T2Treference2T spectrum |
Conforms |
|
|
Test (clarity and colour of methanol solution) |
clear and colorless, if turbid, should conform the rule, if has colour, should conform the rule |
clear and colorless |
|
Acidity |
3.2～4.2 |
3.54 |
|
Loss on drying |
0.5% Max |
0.03% |
|
Heavy Metal (as Pb) |
0.002% Max |
Conforms |
|
Related substance |
Single impurity ≤0.5% Total impurity ≤1.0% |
Conforms |
|
Assay(on dried) |
Calculated on the anhydrous substance, should contain CR21RHR26RClNO·CR4RHR4ROR4 R98.0%～102.0% |
99.5% |
What are the characteristics and advantages of Clemastine fumarate powder?
1. Multi effect anti allergy: In addition to antihistamine H1 receptors, it also has inhibitory effects on mast cell degranulation, anticholinergic activity, and bronchiectasis.
2. Strong anti allergic effects:Clemastine fumarate powder is more effective than chlorpheniramine, and is equivalent or superior to cetirizine and loratadine.
3. Liver and kidney safety is superior to cetirizine and loratadine; Unlike loratadine, it is not metabolized by P450 enzymes and has fewer drug interactions.
4. Minor side effects: The main side effect of loratadine is drowsiness, while cetirizine and loratadine may cause weakness, fatigue, headache, and nasopharyngitis. Although chloramphenicol is a first generation antihistamine with sedative effects, its other side effects are fewer than those of widely used antihistamines.
5. Good safety: Compared with cetirizine and loratadine, it has less impact on the liver and kidneys; Not metabolized by P450 enzymes (not by cetirizine), drug interactions are minimal. The so-called second-generation antihistamines (such as cetirizine, loratadine, astemizole, and terfenadine) do not all exempt central nervous system effects, and some also have cardiac toxicity, such as astemizole and terfenadine, which are therefore contraindicated.
How and where to buy Rebamipide powder wholesale?
We have 8 years of experience in selling legal scientific research drugs and have a good reputation, making us a trustworthy partner.
We ensure the quality of our products through independent experimental testing, and every customer is our VIP.
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A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: The product is for research use only and is not intended for diagnosis, treatment, disease prevention, etc.
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