Rasagiline Powder API CAS 136236-51-6

What is Rasagiline?

Rasagiline powder API is a highly selective, irreversible monoamine oxidase B (MAO-B) inhibitor. As a white to off-white powder, it is a core first-line ingredient in the global treatment of Parkinson's disease. Its mechanism of action involves specifically inhibiting MAO-B activity in the brain, reducing dopamine catabolic processes, and thereby increasing extracellular dopamine levels in the striatum. Compared to first-generation drugs, Rasagiline is more potent, and its metabolite is a non-amphetamine structure, exhibiting significant neuroprotective effects. Clinically, it can be used as monotherapy for early-stage Parkinson's disease patients or in combination with levodopa for adjuvant therapy in mid-to-late-stage patients, making it one of the most promising active pharmaceutical ingredients in the neurology field.

What are the effects of Rasagiline?

Rasagiline Powder API irreversibly inhibits monoamine oxidase-B activity in the brain, reducing dopamine breakdown and increasing central dopamine concentration; it improves motor symptoms of Parkinson's disease such as tremor, rigidity, bradykinesia, and gait abnormalities; it can be used as monotherapy in the early stages, and in combination with levodopa in the middle and late stages to alleviate drug efficacy fluctuations and end-of-dose phenomenon; it has neuroprotective potential, delaying damage to dopaminergic neurons; and it improves patients' daily activities and enhances their quality of life.

Where is Rasagiline used?

Rasagiline Powder API, a high-purity active pharmaceutical ingredient specifically designed for neurodegenerative diseases, is increasingly focused on practical applications in neurological clinical treatment, moving beyond broad pharmaceutical industry terminology. It serves a wider range of needs, including chronic neurological disease management in the elderly, the implementation of specialized clinical medications, the development of complementary medications for geriatric rehabilitation, and precision medicine for neurological diseases. Clinically, this ingredient is primarily used to produce oral medications specifically for Parkinson's disease patients, supplying neurology, geriatrics, and rehabilitation departments in hospitals at all levels for routine diagnosis and treatment. These medications are specifically designed to intervene in the decline of motor function in early to mid-stage Parkinson's patients and serve as a core component in combination therapy regimens for late-stage Parkinson's patients, meeting the long-term prescription needs of chronic diseases in primary care and tertiary hospitals.

MF of Rasagiline

Molecular Formula: C12H13N
Molecular Weight: 171.24
Exact Mass: 171.1048
Melting Point: 149.0 - 153.5°C
Boiling Point: 305.5±30.0 °C
Density: 1.1±0.1 g/cm³
Flash Point: 146.8±20.0 °C

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Product Specification

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FAQ：

Q1: What are the core efficacy advantages of Rasagiline?

A1: Rasagiline is an irreversible, highly selective MAO-B inhibitor that stably increases dopamine levels in the brain. Whether used alone or in combination with other drugs, it improves motor symptoms in Parkinson's disease patients and has significant neuroprotective effects. Its active pharmaceutical ingredient (API) has high purity and few impurities, thus exhibiting good therapeutic stability and suitability for long-term formulation production.

Q2: What guarantees ensure the physicochemical quality of Rasagiline?

A2: Rasagiline powder is a white crystalline powder with a stable melting point and crystal form, conforming to the standards of the United States Pharmacopeia/European Pharmacopoeia. The content of related substances and heavy metals is strictly controlled to ensure good batch-to-batch consistency. It is not easily affected by moisture and deteriorates, making it suitable for tablet production and beneficial for long-term drug storage.

Q3: Which formulations and R&D needs is Rasagiline suitable for?

A3: Primarily used in the preparation of oral tablets for Parkinson's disease. It can be used for generic drug consistency evaluation, formulation development, and pilot-scale amplification. The API purity meets standards and can be directly used for domestic and international drug registration, meeting the compliant production requirements for clinical use and export formulations.

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