Cholic acid exists in the bile of cattle, sheep and pigs, and it is a metabolite related to the host and microbial community. Pure Cholic acid powder is colorless flake or white crystalline powder, which is bitter and sweet after tasting. It can regulate host immunity and microbial toxicity.
| Molecular formula |
|
|
|
Analysis tests |
Standard |
Results |
|
Appearance |
White or off-white powder |
White powder |
|
Identification |
The solution should be blue and purple |
Conform |
|
Loss on drying |
≤1.0% |
0.15% |
|
Residue on ignition |
≤0.3% |
0.1% |
|
Solubility |
The solution should be clear and no significant |
Conform |
|
Assay(C₂₄H₄O₅) |
≥80.0% |
98.9% |
|
Conclusion |
It complies with the requirements of CP2015 standard |
|
What is the function and efficacy of Cholic acid ?
Cholic acid is the main component of bile. Traditionally, it is believed to be an organic acid with a steroid structure that can emulsify fats and promote their digestion. In recent years, it has been confirmed that Cholic acid is a hormone and intracellular signaling molecule involved in systemic metabolic regulation.
In animal experiments in 1997, it was found that bile acid can inhibit obesity, and the concentration of bile acid in the blood fluctuates with meals and fasting. During fasting, bile acids are present in the gallbladder and do not circulate, leading to a decrease in plasma bile acid concentration and promoting the synthesis of new bile acids in the liver. During meals, bile secretion and enterohepatic circulation increase the concentration of plasma bile acids, which helps regulate blood sugar and blood lipids. If combined with dietary fiber, it can promote bile acid excretion and lower blood cholesterol.
In recent years, research on Cholic acid powder has deepened, and it has been found that it directly binds to the transcription factor FXR to activate it, thereby increasing the production of the transcription inhibitory factor SHP. The latter inhibits the gene expression of the bile acid synthesis enzyme CYP7A1, leading to a decrease in bile acid synthesis and avoiding the damage of large amounts of bile acid to cells.
Cholic acid also has systemic regulatory effects, and its hormone receptor is TGR5 on the cell membrane, which exists in epithelial cells, nerve cells, smooth muscle cells, and immune cells of the small intestine and gallbladder. Through the action of TGR5, bile acid promotes the release of the hypoglycemic hormone GLP-1 from endocrine cells in the small intestine. This will promote the peristalsis of the large intestine and avoid constipation; This will promote gallbladder relaxation and increase the storage volume of bile; This will act on macrophages and inhibit inflammation.
A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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