Raltegravir Potassium Powder CAS 871038-72-1
Product:Raltegravir potassium powder
CAS NO.:871038-72-1
Molecular formula:C20H20FN6O5.K
Purity & Grade: 99% HPLC; Food grade
MOQ & Package: 100g; Package according to demand
Shipping: Safe and fast delivery
Store & Shelf life: Cool & dry place; 36 months
Lead Time: about 3 days
Warehouse: USA and Germany warehouse
Certificate:COA; HPLC; MSDS; TDS,etc.
Description
What is Raltegravir potassium powder ?
Raltegravir potassium powder is an orally active potassium salt of Raltegravir, which is an HIV-1 integrase inhibitor used for antiviral therapy in HIV infected individuals aged 2 years and above. However, it cannot be used alone and must be used in combination with other medications. Please note that this product cannot cure AIDS and must be used together with other antiviral drugs. It is recommended to consult a professional doctor or pharmacist for use.
| Product name | Raltegravir potassium powder |
| CAS | 871038-72-1 |
| Molecular formula | C20H20FN6O5.K |
| Molecular weight | 482.511 |
| EINECS Number | 682-461-3 |
| melting point | 155-157°C |
| solubility | NA |
| Storage conditions | -20°C Freezer |
| Appearance | White to light beige |
| boiling point | NA |
| Density | NA |
Product Specification
| Item | Specification | Results |
| Appearance | White powder | Complies |
| Odor | Characteristic | Complies |
| Tasted | Characteristic | Complies |
| Loss on Drying | 5% Max. | 1.02% |
| Sulphated Ash | 5% Max. | 1.30% |
| Extract Solvent | Ethanol & Water | Complies |
| Heavy Metal | 5ppm Max | Complies |
| As | 2ppm Max | Complies |
| Residual Solvents | 0.05% Max. | Negative |
| Total Plate Count | 1000/g Max | Complies |
| Yeast & Mold | 100/g Max | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| Conclusion | Conform with enterprise specification | |
Where is Raltegravir potassium powder usually used?
Raltegravir potassium powder is mainly used to treat HIV infected people aged 2 years and above, and is an integrase inhibitor in the antiviral treatment of AIDS.
In addition, it is also used as a research reagent, such as an analytical standard for research and analytical applications, as well as an integrase inhibitor for studying HIV infection. It also plays an important role in drug development and testing
What are the effects of Raltegravir potassium powder ?
The main effects of Raltegravir potassium powder include:
Inhibition of virus replication: It effectively blocks virus replication by inhibiting HIV-1 integrase. In acute infected human lymphoid CD4+T cell lines MT-4 and CEMx174, it effectively inhibits SIVmac251 replication, with EC90 in the low nanomolar range.
Sensitivity to different mutants: PFVIN carrying S217H substitution showed a 10 fold lower sensitivity to Raltegravir with an IC50 of 900nM. PFVIN exhibited 10% WT activity and was inhibited by Raltegravir with an IC50 of 200nM, indicating a two-fold decrease in sensitivity to IN chain transfer inhibitors (INSTI) compared to WTIN. S217QPFVIN is sensitive to WT enzyme like Raltegravir.
Metabolic pathway: Raltegravir potassium powder is metabolized through glucuronidation rather than liver metabolism. The drug, which is a strong inducer of glucuronidase UGT1A1, significantly reduces the concentration of Raltegravir and should not be used. It has a weak inhibitory effect on the activity of liver cytochrome P450.
Cell permeability: In the presence of magnesium and calcium, its cell permeability decreases.
In summary, it has significant efficacy in treating HIV infection, but its efficacy may be affected by specific mutations and drug interactions. When using, attention should be paid to its metabolic pathways and interactions with other drugs.
How and where to buy Raltegravir potassium powder wholesale?
Our products undergo experimental testing and are recognized by customers.
You can trust our order because we have a good record of selling legal educational drugs.
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A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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Note: This compound is only used for laboratory research purposes. The US authorities have not evaluated these claims. Before use, please consult your doctor and learn about available research. This product is not intended for the diagnosis, treatment, cure, or prevention of any disease.
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