Product description
Pleuromulin is a class of broad-spectrum diterpene antibiotics produced by Pleurotusmutilus, which is the precursor of semi-synthetic derivatives of pleurotusmutilus. Pleurin antimicrobials are a novel family of antimicrobials with good antibacterial activity and resistance, which can effectively inhibit most gram-positive bacteria, mycoplasma and some Gram-negative bacteria.
Pleurin truncatus is a broad-spectrum diterpene antibiotic produced by Pleurus. It can inhibit the protein synthesis of bacteria, thus achieving the effect of inhibiting bacterial growth. It works in a different way than other types of antibiotics. Because C-14 of the truncated pleurin drugs contains free hydroxyl groups, it is not active; By modifying C-14, the derivatives with enhanced antibacterial activity against bacteria and mycoplasma can be obtained.
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COA
| Items | Standard | Result | |
| Appearance | White to pale yellow crystal powder |
Pale yellow crystal powder |
|
| Loss On Drying | ≤2% | 0.5% | |
| Content Pleuromulin |
0 | ≥80% | 87.5% |
| Impurity A | ≤18% | 5.8% | |
| Any Single Impurity |
≤2% | 1.9% | |
| Total Impurity | ≤20% | 8.6% | |
| PH Value | 5~7 | 6.1 | |
| Conclusion | The products are conform with the company standard | ||
Density 1.2± 0.1g /cm3
Boiling point 482.8±45.0 °C at 760 mmHg
Melting point 170-171ºC
Molecular formula C22H34O5
Molecular weight 378.502
Flash point 158.7±22.2 °C
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What is the mechanism of action of Pleuromulin?
Pleuromutilins inhibit bacterial protein synthesis by binding to the central part of domain V of the 50S ribosomal subunit at the peptidyl transferase center (PTC), which prevents the correct positioning of the CCA ends of tRNAs for peptide transfer in the A- and P-site, thereby inhibiting peptide bond formation.
What class of antibiotic is Pleuromulin?
Pleuromutilin belongs to the class of secondary metabolites known as terpenes, which are produced in fungi through the mevalonate pathway (MEP pathway).
What are the derivatives of Pleuromulin?
Antibiotics tiamulin, retapamulin, and valnemulin are the derivatives of fungal metabolite pleuromutilin.
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why choose us
Our Factory
Package
Shipping Methods
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places. |
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7-15 days |
By Air |
Suitable for more than 50kg. |
|
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15-60 days |
By Sea |
Suitable for more than 500kg. |
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