Name: China Pimecrolimus Powder CAS 137071-32-0 Suppliers, Manufacturers, Factory - Wholesale Price - Faithful Biotech
Brand: Faithful
SKU: 298473360

Description

Pimecrolimus powder CAS 137071-32-0 is a novel type of topical immunosuppressant primarily used to treat atopic dermatitis. In recent years, its application has expanded to include various eczematous dermatitis-related skin conditions, such as atopic dermatitis, eczema, contact dermatitis, and perioral dermatitis.

Key Features:
Hormone-free: Does not cause skin thinning, telangiectasia, or steroid dependence.
Suitable for long-term intermittent maintenance therapy, reducing relapse rates.
Compared to Tacrolimus: Less irritating, milder initial burning sensation.

Atopic dermatitis (AD) is an itchy and inflammatory skin disease affecting at least 28 million people in the United States. During an AD flare-up, the skin becomes inflamed and intensely itchy. "Severe flushing" is characterized by persistent or uncontrollable itching, intense erythema, extensive epidermal shedding, and potential exudation and crusting. The overall goal of AD treatment is to minimize the frequency and severity of disease flare-ups.

Tests	Specifications	Results
Appearance	White to off-White Crystalline Powder	Complies
Identification	HPLC Retention Time:RT=12.8±0.2min	Complies
Assay	98.0%-102.0%	99.7%
Related Substances	Individual impurity≤0.5%	0.05%
Related Substances	Total Impurities≤1.0%	0.10%
Loss on Drying	≤1.0%	0.05%
Heavy Metals	≤lppm	Complies
Microbial Limits	Total Aerobic Microbial Count:≤1000 cfu/g	<100cfvg
	Yeast&Moulds:≤100cfu/g-	<10cfuv/g
	Pathogens:Salmonella(Negative per 25g),E coliO157:H7(Negative per 10g)	Negative
	Salmonella Negative	Negative
Conclusion	Conform with enterprise specification

Density: 1.2±0.1 g/cm³
Boiling point: 866.1±75.0 °C at 760 mmHg
Molecular formula: C₄³H₆₈ClNO₁₁
Molecular weight: 810.453
Flash point: 477.6±37.1 °C
Exact mass: 809.448120
PSA: 158.13000
LogP: 5.08

Pimecrolimus is a lipophilic, anti-inflammatory derivative of ascomycin macrolactam that selectively inhibits the production and release of pro-inflammatory cytokines. Pimecrolimus has a high affinity for Macrophilih-12 and inhibits the calcium-dependent phospholipase neurotrophin. Therefore, it blocks the synthesis of inflammatory cytokines within T cells. In animal models of skin inflammation, Pimecrolimus exhibits strong anti-inflammatory activity after topical or systemic application. In a pig model of non-allergic contact dermatitis, topical Pimecrolimus is comparable in effect to potent corticosteroids. Unlike corticosteroids, Pimecrolimus does not cause skin atrophy in pigs or affect Langerhans cells in mouse skin.

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With our continuous efforts and good service, we sincerely hope to establish long-term cooperation and common development with customers and give us a chance. We believe that we will satisfy you with first-class quality, safe and fast delivery and enthusiastic after-sales service.

Pimecrolimus powder CAS 137071-32-0

Transportation Time	Shipping method	Cargo weight requirements	Advantage
3-7 days	DHL,Germany DHL,Germany DPD, UPS,USPS,FedEx,TNT,EMS	Suitable for under 50kg. International door to door express	We have warehouses in Germany and California, USA, and customers in Europe and America can enjoy sending goods directly from these two places.
7-15 days	By Air	Suitable for more than 50kg. fast and cheaper for large order
15-60 days	By Sea	Suitable for more than 500kg. Cheapest shipping way

Temporary local burning, stinging, and slight redness are common and usually subside on their own as the skin develops a better tolerance.

Store in a cool, dry place away from light and heat sources, in a sealed container.

You can contact the following email address: sales4@faithfulbio.com

Disclaimer: All conventional products (non-customized products) pictures are taken in kind, but due to the influence of light (different time, different background light), shooting method, different display equipment parameters and other factors, there may be some differences between the picture and the real color, product color, please take the real effect prevail, product color difference is not a product quality problem.

Note: Always consult a qualified health practitioner before taking any new medication. This product is not intended to diagnose, treat, cure or prevent any disease.At the time of purchase, the international buyer agrees to assume the risk of all items arriving. We cannot replace lost or impounded items. Before sending items, you need to confirm that you agree to these terms.This is only a recommended dose based on our own experience and anecdotal evidence. We recommend that you do your own research before using this product.

Statement: This product is only used for scientific research, and the consequences of other uses are not responsible.

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Pimecrolimus Powder CAS 137071-32-0

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FAQ

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