What is API Powder Nimodipine ?
Nimodipine is an important pharmaceutical active ingredient. API Powder Nimodipine is usually white-like, which is widely used in the medical field. It is mainly used to produce products for treating cerebral vasospasm, improvement of blood circulation in the recovery period of acute cerebrovascular disease and other related diseases. It has strong fat solubility and can penetrate the blood-brain barrier, but it has poor solubility in water and has certain solubility in organic solvents. It should be stored in the dark and at low temperature to ensure its stability.
| Product name |
API Powder Nimodipine |
| CAS | 66085-59-4 |
| molecular formula | C21H26N2O7 |
| Molecular weight | 418.44 |
| EINECS number | 266-127-0 |
| melting point | 125°C |
| boiling point | 536.21°C (rough estimate) |
| density | 1.3268 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| The acidity coefficient (PKA) | 2.77±0.70(Predicted) |
| Storage condition | Sealed in dry,Room Temperature |
What is the action mechanism of API Powder Nimodipine ?
1. Core mechanism
As an L-type voltage-gated calcium channel antagonist, API Powder Nimodipine selectively blocks L-type calcium channels on vascular smooth muscle and neurons, significantly reduces Ca2+ influx, thus inhibiting vasospasm, cytotoxicity and neuronal excitability abnormality triggered by calcium overload. Its pharmacological feature is that it is more selective to cerebral vessels, and can improve cerebral blood flow (CBF) and microcirculation without significantly lowering blood pressure.
2. Neuroprotection at cellular and molecular levels
By inhibiting pathological calcium influx, it reduces mitochondrial calcium overload and reactive oxygen species generation, stabilizes mitochondrial membrane potential and function, reduces cytochrome C release and activation, and inhibits stress/ischemia-induced apoptosis pathway. At the same time, it can activate the signal, up-regulate the expression of anti-apoptosis and neurotrophic related genes, and show a wide range of cell type protection effects on neurons, astrocytes and Schwann cells.
3. Relationship with cerebral vasospasm and brain injury
In situations such as subarachnoid hemorrhage, it can reduce the risk of ischemia-reperfusion injury and delayed ischemic brain injury by relieving cerebral vasospasm, improving microcirculation and protecting blood-brain barrier. Part of its clinical benefit is considered to be related to direct neuroprotection besides its vascular effect.
4. Key points of pharmacokinetics and tissue selectivity
Its fat solubility is strong, and its distribution in brain tissue and receptor occupancy rate are better than most antagonists. API Powder Nimodipine can inhibit the uptake of vascular smooth muscle and neurons, and reduce the neurological deficit and infarct volume in various animal models of cerebral ischemia/reperfusion.
Product Specification
| Items | Specifications | Results |
|
Appearance |
White powder | Complies |
| Assay (HPLC) | 98.0% -102% | 99.26% |
| Water Content | ≤ 0.50% | 0.23% |
|
Heavy Metals |
≤20ppm |
<20ppm |
|
Microbial Limit |
≤20ppm |
<20ppm |
| Yeast &Mold | ≤50cfu/g | <10cfu/g |
| Coliforms | ≤3cfu/g | <3cfu/g |
| E.Coli | Negative/10g | Negative |
| Salmonella | Negative/25g | Negative |
| S.aureus | Negative/25g | Negative |
| Conclusion: The test results are conformed to the in-house specification | ||
How and where to buy API Powder Nimodipine wholesale ?
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A variety of shipping methods for you to choose
|
Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
DHL, Germany DHL, Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
|
7-15 days |
By Air |
Suitable for more than 50kg. |
|
|
15-60 days |
By Sea |
Suitable for more than 500kg. |
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FAQ:
Q1:What are the packaging specifications of API Powder Nimodipine?
A1:Conventional packaging: laboratory/small test: 50g/100g/500g (sterile bag+aluminum foil bag+cardboard box, sealed from light); Pilot/mass production: 1kg/5kg/10kg/25kg (sterile bag+double aluminum foil bag+cardboard barrel/fiberboard barrel, lined with moisture-proof PE film).
Q2: How to ensure transportation safety?
A2:During transportation, the light-proof outer box+shockproof filling is adopted, and the default is international logistics (DHL/FedEx/EMS or whole container by sea), and the risk is classified as non-dangerous.
Q3: Is your Nimodipine API or industrial grade? Does it meet the medical standards?
A3: We supply API-grade nimodipine powder for medical use, and the production follows the requirements of good manufacturing practices and target market regulations, and provide COA (quality inspection report) and other documents to prove that its purity, impurities and stability meet the medical standards, and the specific specifications can be customized according to customer needs (such as USP, EP, CP and other pharmacopoeia standards).
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Attention: It should be noted that this product is not intended for the diagnosis, treatment, cure, or prevention of any disease. Please consult your doctor and learn about available research before use. Please do not use without authorization. This compound can only be used for research purposes. The US Food and Drug Administration has not evaluated these claims.
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