What is Glibenclamide?
Glibenclamide powder is white crystalline powder; Almost odorless. Slightly soluble in chloroform, slightly soluble in ethanol, acetone and chloroform, insoluble in water or ether.
Glibenclamide is a hypoglycemic drug, which is mainly used in patients with type 2 diabetes. It belongs to sulfonylureas. One of the causes of type 2 diabetes is that insulin produced by islet cells in the body is reduced, and insulin can lower blood sugar. If the insulin level decreases, the blood sugar of human body will increase and lead to diabetes. Glibenclamide can stimulate functional islet cells to produce insulin and increase insulin levels in the body, so it can play a role in lowering blood sugar. Because the cause of type 1 diabetes is the complete loss of insulin cell function, even using Glibenclamide can not stimulate islet cells to produce insulin, so Glibenclamide is ineffective for type 1 diabetes. It is only effective for type 2 diabetes with certain islet function.
| Product name | Glibenclamide |
| CAS | 10238-21-8 |
| Molecular formula | C23H28ClN3O5S |
| Molecular weight | 494 |
| EINECS Number | 233-570-6 |
| Storage condition | 2-8°C |
| Melting point | 173-175°C |
| Solubility | Ethanol: soluble 2mg/mL. |
| Appearance | White powder |
| Density | 1.1805 (rough estimate) |
| Stability | It can be stored in DMSO or ethanol solution at-20 for up to 3 months. |
How does Glibenclamide work?
Product Specification
| Item | Specification | Results |
| Appearance | Powder | Complies |
| Color | White fine Powder | Complies |
| Particle Size | 100% pass 80 mesh | Complies |
| Oder | Characteristic | Complies |
| Taste | Characteristic | Complies |
| Loss on Drying | ≤5.0% | 2.20% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Residual acetone | ≤0.1% | Complies |
| Residual Ethanol | ≤0.5% | Complies |
| Heave Mentals | ≤10ppm | Complies |
| Na | ≤0.1% | <0.1% |
| Pb | ≤3 ppm | Complies |
| Total Plate | <1000CFU/g | Complies |
| Yeast & Mold | <100 CFU /g | Complies |
| E. Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| Conclusion: Conform with USP Standard | ||
What is the main function of Glibenclamide?
Glibenclamide is a sulfonylurea hypoglycemic drug with strong hypoglycemic effect, mainly in several aspects:
1. Promoting islet β cells to secrete insulin, but there is a prerequisite that islet β cells in human body also have certain functions of synthesizing and secreting insulin.
Second, reduce blood sugar by increasing the level of insulin in portal vein.
Third, it directly acts on the liver, inhibiting the decomposition of hepatic glycogen and glycogen heterogenesis, leading to the decrease of hepatic glucose production and output, thus lowering blood sugar.
Fourth, increase the sensitivity of extrapancreatic tissue to insulin and the utilization of sugar, thus reducing blood sugar.
Therefore, Glibenclamide powder can reduce both fasting blood glucose and postprandial blood glucose.
HTML5 atlas of Glibenclamide
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Is glibenclamide same as metformin?
1, the mechanism of action is different.
Metformin can reduce blood sugar mainly by reducing the glucose output of liver and increasing the sensitivity of peripheral tissues to insulin. Glibenclamide mainly increases the secretion of insulin in the body, inhibits the glucose output of the liver and increases the sensitivity of peripheral tissues to insulin.
2. The adverse reactions of drugs are different.
Metformin may cause nausea, vomiting, diarrhea and other adverse reactions. Glibenclamide may have adverse reactions such as nausea, diarrhea and headache.
3. Different taboos
Metformin is a biguanide hypoglycemic drug, and its contraindications are diabetic ketoacidosis, severe infection, major surgery and hypoglycemia. Glibenclamide belongs to sulfonylurea hypoglycemic drugs, and its contraindications are diabetic ketoacidosis, severe burns, infection, major surgery and hypoglycemia.
Which is better, Glimepiride or Glibenclamide?
1. Glibenclamide is the first generation of sulfonylurea hypoglycemic agents, and glimepiride is the third generation of sulfonylurea hypoglycemic agents;
2. The hypoglycemic effects of glimepiride and glibenclamide are different. Glimepiride has the characteristics of long-acting effect, regulating insulin secretion and low risk of hypoglycemia, while glibenclamide has short-acting effect and high risk of hypoglycemia, so it is rarely used at present.
What are the precautions of Glibenclamide?
1. A few patients have gastrointestinal discomfort, fever, skin allergy and hypoglycemia symptoms, and should be reduced or stopped.
2. Patients with liver dysfunction should be carefully collected and sorted by medical education network.
3. Severe decompensated acidosis, diabetic coma, renal insufficiency, diabetic ketosis and young people, children and pregnant women are not suitable for application.
This medicine has mild diuretic effect.
5. Insulin-dependent diabetes mellitus with acute complications, pregnancy and liver and kidney dysfunction are prohibited.
How and where to buy Glibenclamide Powder wholesale?
You can trust our order because we have a good record of selling legal educational drugs.
We conduct independent laboratory tests on all products and then sell them to our respected customers.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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