Phentolamine Mesilate Powder CAS 65-28-1

Phentolamine Mesilate Powder is an α-adrenergic receptor blocker with the chemical formula of C18H23N3O4S. By blocking α-adrenergic receptor and indirectly exciting β-adrenergic receptor, it can rapidly dilate peripheral blood vessels, significantly reduce peripheral blood vessel resistance, increase peripheral blood volume and improve microcirculation. In recent years, it has been used more and more widely.

What is an α -adrenergic receptor blocker?

Alpha receptor blockers refer to those that can selectively bind to alpha adrenergic receptors without stimulating or weakening the activation of adrenergic receptors, but can block the corresponding neurotransmitters and drugs from binding to alpha receptors, thereby producing anti adrenergic effects. Phentolamine mesylate is a short acting, non selective alpha receptor (a1, a2) blocker. This class of drugs has weak binding affinity with alpha receptors, is easy to dissociate, has mild effects, and has a short maintenance time (1-1.5 hours). Due to the competition between this type and agonists, it is also known as competitive alpha receptor blockers.Our company can provide various products to improve the circulation system, such as Phentolamine mesilate, Vinpocetine, Nebivolol, Lercanidipine, etc. If you are interested or have new procurement plans, please contact us via email:sales6@faithfulbio.com

What are the clinical applications of Phentolamine mesilate?

Phentolamine Mesilate Powder, as an effective product for improving cardiovascular system, can deal with many cardiovascular and cerebrovascular problems.For example, it is used to diagnose pheochromocytoma and treat its induced hypertension attacks, left ventricular failure, and prevent skin necrosis.In addition, it can be used as an auxiliary product to improve human function in the face of diabetes, kidney disease, toxic enteroparalysis, acute respiratory distress syndrome, bronchiolitis, severe asthma, etc.In particular, pure Phentolamine mesylate can relax the smooth muscle of the corpus cavernosum, let more blood flow into the corpus cavernosum, and prevent the blood from flowing out of the corpus cavernosum, leading to erection.and while maintaining erectile function, it can be unaffected by sex hormones, emotions and nerves, thus maintaining and promoting long-term erection.Therefore, more and more people began to treat erectile dysfunction in clinic. According to clinical data, it takes about 30 minutes to take effect, and the effective concentration can last for about two hours.

What are the side effects of this product?

Long term experiments have shown that phentolamine mesylate has no significant carcinogenic, mutagenic, or reproductive toxicity. However, it should be noted that it has little effect on the blood pressure of normal individuals or patients with primary hypertension. In addition, in addition to conventional adverse reactions such as nasal congestion, dizziness, fatigue, chest tightness, etc. This product has potential cardiovascular side effects, such as palpitations, facial flushing, and a very small number of people may have changes in systolic and diastolic blood pressure. A very small number of patients may have orthostatic hypotension. Therefore, this product needs to be studied or used under the guidance of your doctor. It should be noted that if you are using this product and may have low blood pressure, severe arteriosclerosis, angina pectoris, myocardial infarction, liver and kidney dysfunction, gastric ulcers, or allergies to this product, it is recommended not to use it.

What is the difference between short-acting α receptor blockade and long-acting α receptor blockade?

According to the different duration of drug action, α receptor blockers can be divided into two categories.One kind of drugs can compete with catecholamine for receptors and play an alpha receptor blocking role, which is called short-acting alpha receptor blocking drugs because of its weak binding with alpha receptors, rapid onset and short maintenance time. Also known as competitive alpha receptor blockade. Commonly used are Phentolamine Mesylate and Tolazoline hydrochloride.The other kind is called long-acting α -receptor blockers because of its covalent bond with α-receptor, firm binding and strong receptor blocking effect for a long time. Also known as non-competitive α receptor blockers, such as Phenoxybenzamine hydrochloride and Prazosin.

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Our company has passed FDA and ISO19001 quality management system certification. And we have internal cooperation agreements with multiple factories and laboratories in China, Therefore, We can provide you with the required Phentolamine mesilate,Vinpocetine,Nebivolol,Lercanidipine and other products.

We not only have unique advantages in transportation, but also support multiple payment methods, whether you use US dollars, euros, Australian dollars, or local currencies from Singapore, Malaysia, Thailand, and so on. We can also support local currencies in these regions and countries. In addition, we also support bank cards (credit cards, etc.) for payments.

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