Monepantel CAS 887148-69-8

Monepantel is an anthelmintic approved for use in sheep and cattle to control gastrointestinal nematodes. It is a new kind of insect repellent and a positive regulator of nAChR. Called aminoacetonitrile derivative (AAD).It is often sold in combination with macrolide Abamectin .In clinical applications, the addition of Monepantel-D5 can effectively compensate for the shortcomings of using avermectin raw materials, such as the inability of avermectin CAS.NO:71751-41-2 to kill insect eggs, which may lead to secondary crimes in pets; Although avermectin can affect the neural transmission system of insects, its mechanism of action is still limited to paralyzing mites, making them inactive and not feeding, but it does not cause rapid dehydration of insects. Although this can protect beneficial insects and pets on plants, it is beneficial. However, this also leads to a slow lethal efficiency of parasites using avermectin raw materials. When treating pets, pets still have to endure the invasion of parasites, which is very unfriendly to parasitic pets.

What is the mechanism of action of Monepantel?

Studies using molecular genetic methods have shown that when Monepantel acts on nematodes, active AADs act through ligand gated ion channels. Further research has confirmed that the DEG-3 subfamily of nicotinic acetylcholine receptors may be a putative target of Monepantel-D5. In 2009, researchers published an article suggesting that MPTL-1 may be a binding site for monepantel in Haemonchus contortus. The latest research shows that the binding of AADs and Monepantel enhances the DEG-3/Des-2 receptor of twisted and deformed Haemophilus influenzae. If used as an agonist of nicotinic acetylcholine receptors, it can also produce spastic paralysis or lead to nematode death. However, only the structure of the S-enantiomer is active against gastrointestinal nematodes. Monepantel powder has been further validated in rodent parasite models. Researchers have isolated a lead compound and named it AAD 1566 isomer, which can completely eliminate pathogenic nematodes in sheep and cattle at doses of 2.5 mg/kg and 5.0 mg/kg, respectively.

What are the precautions for deworming with Monepantel, taking lambs as an example?

Before using Monepantel, it is necessary to conduct small group experiments on sheep to prevent serious losses. Clinical applications have shown that Monepantel-D5 can be used for both in vivo and in vitro pest control of sheep. The main target of in vivo pest control is nematodes, while the main target of in vitro pest control is parasites; The mixed powder of ivermectin and Monepantel is currently a commonly used anthelmintic drug (used when sheep suffer from parasitic diseases), with high safety. Even when used on pregnant ewes, it will not have a significant impact.
1. Lamb deworming: The first deworming of lambs should be done at 50 days of age, the second deworming should be done at 90 days of age, and deworming should be done every 3 months thereafter.
2. Sheep deworming: Sheep can generally be dewormed once a year in spring and autumn, and after 10 days of deworming each time, another deworming work needs to be carried out to enhance the deworming effect.
3. Deworming for fattening sheep: The suitable deworming time for fattening sheep is from March to April and September to October every year. If the harm of parasites is severe, deworming work can be added once in June to July.
4. Deworming of ewes: deworming of ewes with a mixture of ivermectin and Monepantel-D5 powder should be carried out once 25 days before mating, and another deworming should be carried out after a 7-day interval; If the ewe is already pregnant, it should wait for about 20 days after giving birth before deworming. If deworming is necessary during pregnancy, it is necessary to avoid the two time periods of 45 days before pregnancy (at the beginning of pregnancy) and 45 days before delivery.

What are the adverse reactions of Monepantel?

Monepantel powder is a safe medication that is highly suitable for various treatment options. Especially, it can compensate for the shortcomings of ivermectin, making the use of this product closely related to ivermectin and opening up a large market. Currently, there are relatively few reported adverse reactions, but, In Australia, New Zealand, Uruguay, Brazil, the Netherlands and the United Kingdom, etc. When used alone, this product has shown poor efficacy, These reports have shown a number of species were resistant to monepantel, including Haemonchus contortus, Teladorsagia circumcincta, Trichostrongylus colubriformis, and Oesophagostomum.

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