4-Hydroxythiobenzamide CAS 25984-63-8
Product Name:4-Hydroxythiobenzamide;4-Hydroxybenzothioamide;Febuxostat Intermediate;p-HydroxyThioBenzamide;HydroxythiobenzaMide;4-hydroxy thiobenzam
CAS NO.:25984-63-8
Molecular formula：C7H7NOS
Purity & Grade: 99% HPLC; Medicine grade
MOQ & Package: 100g; Package according to demand
Shipping: Safe and fast delivery
Store & Shelf life: Cool & dry place; 24 months
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
Certificate:COA; HPLC; MSDS; TDS,etc.
Description
What is 4-Hydroxythiobenzamide?
The structure of 4-Hydroxythiobenzamide contains a thiocarbonyl unit and phenol structure, which has certain acidity. Phenol hydroxyl units can be methylated with methyl iodide under the action of alkali to obtain the corresponding phenol ether products. In addition, thiocarbonyl units can undergo condensation reaction with amino alcohols to obtain the corresponding thiocycloamide derivatives.
4-Hydroxythiobenzamide powder is light yellow powder, insoluble in water but soluble in alcohol organic solvents. This characteristic makes it show unique advantages in organic synthesis and drug preparation. 4-Hydroxythiobenzamide is a common pharmaceutical chemical raw material, which can be used in the production and preparation of drug molecule febuxostat. In addition, it can also be used as an organic synthesis intermediate, and can be used to synthesize an effective CDK5 inhibitor for treating Alzheimer's disease.
| Product name | 4-Hydroxythiobenzamide |
| CAS | 25984-63-8 |
| Molecular formula | C7H7NOS |
| Molecular weight | 153.2 |
| EINECS Number | 674-712-0 |
| Storage condition | Keep in dark place,Inert atmosphere,Room temperature |
| Melting point | 181-185℃ |
| Solubility | Soluble in DMSO (a little) and methanol (a little) |
| Appearance | Pale yellow powder |
| Boiling point | 320.4±44.0 °C(Predicted) |
| Density | 1.338±0.06 g/cm3(Predicted) |
What is the pharmacological action of 4-Hydroxythiobenzamide?
The occurrence of gout is due to the excessive production of uric acid in the body and the decrease of renal clearance ability, and the accumulation of uric acid in the body leads to the deposition of urate crystals in joints and organs. Therefore, gout is usually treated by promoting uric acid excretion and inhibiting uric acid production, and taking appropriate measures to improve related symptoms. The production of uric acid in the body is related to purine metabolism. In the last step of purine metabolism, hypoxanthine generates xanthine under the action of xanthine oxidoreductase (XOR), and then further generates uric acid. Inhibition of the activity of this enzyme can effectively reduce the production of uric acid. 4-Hydroxythiobenzamide is a newly developed XOR inhibitor in the world. It can reduce uric acid synthesis and uric acid concentration in vivo by highly selectively acting on this oxidase, thus effectively treating ventilation diseases.
Product Specification
| Item | Specification | Results |
| Appearance | Yellow Powder | Complies |
| Oder | Characteristic | Complies |
| Taste | Characteristic | Complies |
| Loss on Drying | ≤5.0% | 2.20% |
| Residue on Ignition | ≤0.1% | 0.05% |
| Residual acetone | ≤0.1% | Complies |
| Residual Ethanol | ≤0.5% | Complies |
| Heave Metals | ≤10ppm | Complies |
| Total Plate | <1000CFU/g | Complies |
| Yeast &Mold | <100 CFU/g | Complies |
| E.Coli | Negative | Complies |
| Salmonella | Negative | Complies |
| Assay | ≥99.0% | 99.37% |
| Conclusion: | Conform with enterprise specification. | |
What is the application of 4-Hydroxythiobenzamide?
1. Drug synthesis: First of all, 4-Hydroxythiobenzamide plays an important role in drug synthesis. As an intermediate of febuxostat (a drug for treating hyperuricemia in gout patients), 4-Hydroxythiobenzamide plays a key role in the production and preparation of febuxostat. The plasma protein binding rate of febuxostat is about 99.2%, which is suitable for long-term treatment of hyperuricemia in gout patients, but its preparation process is complicated, and the preparation of 4-Hydroxythiobenzamide is the key link.
2. Intermediates of organic synthesis: In addition to drug synthesis, 4-Hydroxythiobenzamide can also be used as intermediates of organic synthesis. Its structure contains thiocarbonyl units and phenol structure, which makes it have certain acidity and reactivity. In organic synthesis, it can react with many compounds to produce compounds with specific structures and functions. For example, phenolic hydroxyl units can be methylated with methyl iodide under the action of alkali to obtain the corresponding phenolic ether products; Thioconyl units can undergo condensation reaction with amino alcohol compounds to obtain corresponding thiocycloamide derivatives.
HTML5 atlas of 4-Hydroxythiobenzamide
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Compared with allopurine, does 4-Hydroxythiobenzamide have obvious advantages?
1. Allopurinol can only inhibit the reduced XOR, while 4-Hydroxythiobenzamide can significantly inhibit the oxidized XOR and the reduced XOR, so its effect of reducing uric acid is more powerful and lasting;
2. Allopurinol is a purine analog, which inevitably affects the activities of other enzymes involved in purine and pyridine metabolism. Therefore, in the treatment of allopurinol, it is necessary to repeat large doses to maintain a high drug level. This also brings serious and even fatal adverse reactions caused by drug accumulation. However, 4-Hydroxythiobenzamide is a non-purine XOR inhibitor, so it has better safety.
What should we pay attention to when using 4-Hydroxythiobenzamide?
1. Please wear appropriate personal protective equipment, such as gloves and goggles, when using 4-Hydroxythiobenzamide.
2. It should be stored in a dry and cool place, and away from fire sources and oxidants.
3. Please follow the correct operation method during use and pay attention to the relevant safety regulations. If there is any discomfort or accident, please seek medical advice or contact a professional.
How and where to buy 4-Hydroxythiobenzamide powder wholesale?
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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