Losartan Powder API CAS 114798-26-4

What is Losartan?

Losartan Powder API is an angiotensin II receptor antagonist (ARB) antihypertensive drug substance, usually existing as losartan potassium, as a white to off-white crystalline powder. This compound exerts its antihypertensive effect by selectively blocking the binding of angiotensin II to AT1 receptors, inhibiting vasoconstriction and aldosterone secretion. As the world's first marketed ARB drug, Losartan, developed by Merck, is a first-line core active pharmaceutical ingredient for treating hypertension, diabetic nephropathy, and reducing the risk of stroke.

How Losartan manages high blood pressure and related cardiovascular risks?

Losartan Powder API is primarily used in the treatment of cardiovascular and renal diseases, covering several important clinical indications. In the treatment of hypertension, this active pharmaceutical ingredient (API) is suitable for adults and children aged 6 years and older, reducing the risk of fatal and non-fatal cardiovascular events (primarily stroke and myocardial infarction) by lowering blood pressure. In the prevention of cerebrovascular diseases, Losartan is approved for use in hypertensive patients with left ventricular hypertrophy to reduce the risk of stroke. In renal protection, this API is suitable for patients with type 2 diabetic nephropathy accompanied by elevated serum creatinine and proteinuria, slowing the progression of renal function deterioration. Furthermore, in pharmaceutical formulation manufacturing, Losartan Powder API is a core component in the preparation of various oral solid dosage forms and is widely used in generic drug development and the production of combination antihypertensive preparations.

How Losartan achieves precise blood pressure reduction by blocking AT1 receptors?

The core mechanism of action of Losartan Powder API is to exert its antihypertensive and target organ protective effects by selectively blocking the AT1 receptor of angiotensin II. Angiotensin II is the main active hormone in the renin-angiotensin system, with strong vasoconstrictive effects and can stimulate the adrenal cortex to secrete aldosterone, leading to water and sodium retention and elevated blood pressure. Losartan and its main active metabolite can selectively bind to AT1 receptors in various tissues such as vascular smooth muscle and adrenal glands, competitively blocking the binding of angiotensin II to this receptor, thereby inhibiting its vasoconstrictive and aldosterone secretion effects. Notably, Losartan has an affinity for the AT1 receptor that is approximately 1000 times higher than that for the AT2 receptor, and does not possess partial agonist activity; its active metabolite is 10-40 times more potent than the original drug, exhibiting a reversible, non-competitive inhibitory effect.

Furthermore, Losartan Powder API does not inhibit angiotensin-converting enzyme, nor does it bind to other hormone receptors or ion channels important for cardiovascular regulation; therefore, its antihypertensive effect is highly specific and does not cause common adverse reactions of ACE inhibitors such as dry cough.

MF of Losartan

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FAQ：

Q1: What are the advantages of Losartan in terms of efficacy?

A1: It has strong receptor blocking selectivity, a stable and long-lasting antihypertensive effect, a mild effect and good tolerability, and consistent efficacy across batches, ensuring stable clinical efficacy of the finished drug.

Q2: What are the characteristics of Losartan powder and its physicochemical properties?

A2: The powder has a uniform and fine texture, is not prone to moisture absorption and clumping, and strictly meets standards for moisture, heavy metals, and related substances. It remains stable during storage and formulation processing.

Q3: Does Losartan meet domestic and international compliant supply requirements?

A3: The raw materials are sourced from GMP-certified factories, each batch comes with complete quality inspection documents, and third-party testing is supported, meeting the requirements for drug registration and export.

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