Lithocholic Acid CAS 434-13-9
Product Name:Lithocholic acid;Lithocolic acid;Lithocholate;lithocholic-acid
CAS NO.:434-13-9
Molecular formula：C24H40O3
Purity & Grade: 99% HPLC; Medicine grade
MOQ & Package: 100g; Package according to demand
Shipping: Safe and fast delivery
Store & Shelf life: Cool & dry place; 24 months
Lead Time: 1-3 days
Warehouse: USA and Germany warehouse
Certificate:COA; HPLC; MSDS; TDS,etc.
Description
What is Lithocholic acid?
Lithocholic acid is a secondary Sodium cholate, which exists in bile of higher vertebrates. Its molecular structure contains both hydrophilic groups and hydrophobic groups, so the three-dimensional configuration of Sodium cholate has hydrophilic and hydrophobic properties, which makes Sodium cholate have strong interface activity. It is found that lithocholic acid has many pharmacological activities, such as inhibiting tumor growth, selectively killing breast cancer cells and selectively inhibiting the activity of mammalian DNA polymerase.
Lithocholic acid is an organic acid. It is one of the main derivatives of oleanolic acid. Lithocholic acid powder is white crystalline powder, odorless and soluble in water and ethanol.
Lithocholic acid is not directly synthesized by cholesterol in the liver, but is produced by chenodeoxycholic acid through bacterial metabolism in the intestine. Most of this substance produced in the intestine is excreted together with feces, and a little of it is absorbed, and a binding reaction occurs in the liver, and it appears in bile in the form of taurolithocholic aCld or glyclithocholic aCld.
| Product name | Lithocholic acid |
| CAS | 434-13-9 |
| Molecular formula | C24H40O3 |
| Molecular weight | 376.57 |
| EINECS Number | 207-099-1 |
| Storage condition | room temp |
| Melting point | 183-188 °C (lit.) |
| Solubility | Chloroform (slightly soluble), dichloromethane (slightly soluble, heated), DMSO (slightly soluble, heated) |
| Appearance | White to off-white powder |
| Boiling point | 445.09°C (rough estimate) |
| Density | 1.0454 (rough estimate) |
How does lithocholic acid work?
Low concentration of Lithocholic acid can make BE(2)-m17 and SK-n-MCIXC cells sensitive to cell death induced by hydrogen peroxide, and a certain concentration of LCA can make the original culture of human neuron cells have certain resistance to this type of cell death. Lithocholic acid can kill BE(2)-m17 and SK-n-MCIXC cells not only by triggering the permeability of mitochondrial outer membrane and the internal death path driven by the activation of initiator CASPASE-9, but also by the external death path involving the activation of initiator CASPASE-8. These internal and external pathways of tumor cell death can be interpreted by the cascade reaction of apoptosis.
Product Specification
| Item | Specification | Results |
| Appearance | White Crystalline Powder | White Crystalline Powder |
| Assay | ≥99.00% | 99.81% |
| Mesh Size | 100 %pass 80 mesh | Complies |
| Loss on drying | ≤1.00% | 0.62% |
| Heavy Metals | ≤1.00 | Complies |
| Total impurity | ≤0.5% | 0.12% |
| Residue of Pesticide | Negative | Negative |
| Yeast&Mold | ≤100cfu/g | Complies |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion: | Conform with enterprise specification. | |
What is the in vivo study of Lithocholic Acid?
Lithocholic Acid is a hydrophobic secondary bile acid, which is formed by 7α- dehydroxylation of chenocholic acid, an intestinal bacteria. Lithocholic Acid causes intrahepatic cholestasis (bile flow stops or is blocked). Lithocholic Acid activates PXR (pregnane X receptor), and severe liver injury induced by Lithocholic Acid can be protected by PXR activation. Lithocholic Acid is a ligand of farnesol X receptor (FXR), and its EC50 is 3.8 μ m.. Lithocholic Acid directly binds to VDR (vitamin D receptor) with a Ki of 29μM, activates VDR (vitamin D receptor) with a Ki of 30μM, which is more sensitive than other nuclear receptors (such as PXR, FXR), and its toxic effect is therefore inhibited. Lithocholic Acid has tumor-promoting activity and inhibits mammalian DNA polymerase β with IC50 of 15 μ m..
HTML5 atlas of Lithocholic acid
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IR1 of Lithocholic acid
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What should we pay attention to when using Lithocholic acid?
Lithocholic Acid is an organic acid, which is corrosive to some extent. Appropriate protective equipment, such as gloves and goggles, should be worn during operation. At the same time, avoid contact with skin and inhalation of its vapor. When stored, it should be kept in a sealed container, away from fire sources and oxidants.
How and where to buy Lithocholic acid powder wholesale?
You can trust our order because we have a good record of selling legal educational drugs.
We conduct independent laboratory tests on all products and then sell them to our respected customers.
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Note: This compound should be used for research purposes only. These claims have not been evaluated by the Food and Drug Administration. Please consult your doctor and learn about available studies before using them. This product is not intended to diagnose, treat, cure, or prevent any disease.
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