Product Introduction
Fluconazole powder is a fluorotriazole antifungal drug, white to yellowish white crystalline powder, slightly odorous and bitter. It is easily soluble in glacial acetic acid, methanol or ethanol, poorly soluble in water, and almost insoluble in ether. The antibacterial spectrum is similar to that of ketoconazole, and its antibacterial activity is stronger than that of ketoconazole. Its mechanism of action is to inhibit ergosterol synthase, an essential component of fungal cell membrane, so that ergosterol synthesis is blocked, the integrity of fungal cell wall is destroyed, and its growth and reproduction are inhibited. This product has strong antibacterial activity against Candida albicans, Microsporum, Cryptococcus neoformans, Epidermophyton and Histoplasma capsulatum.
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Product Application
The effects of fluconazole powder are as follows
1. Systemic candidiasis: including candidemia, disseminated candidiasis and other forms of invasive candidal infections.
2. Cryptococcal disease: including cryptococcal meningitis and cryptococcal infections in other parts (such as lungs and skin).
3. Mucosal candidiasis: can be used for patients with normal or impaired immune function.
4. Fluconazole can also replace itraconazole for the treatment of blastomycosis and histoplasmosis.
5. Acute or recurrent vaginal candidiasis.
6. This product can be used for preventive treatment of leukemia patients and other malignant tumor patients who are prone to fungal infections during chemotherapy or radiotherapy.
7. Coccidioidomycosis.
8. Dermatophyte diseases: including tinea corporis, tinea manuum, tinea pedis, tinea versicolor, tinea capitis, onychomycosis and other skin fungal infections.
9. Fluconazole can be used to treat skin pigmentation fungal diseases.
Method 1: 1H-1,2,4-triazole can be obtained from formamide, hydrazine hydrate and 85% formic acid. Meta-difluorobenzene can be obtained from meta-phenylenediamine, and then bromination can be obtained to obtain 2,4-difluorobromobenzene. Magnesium is dissolved in anhydrous ether, and the ether solution of 2,4-difluorobromobenzene is added dropwise under ultrasonic irradiation, and then the ether solution of 1,3-dichloroacetone is added dropwise under ice bath cooling, and stirred at room temperature overnight.
Recrystallization from ethyl acetate-cyclohexane (1:1) can obtain fluconazole, with a total yield of 33.6% and a melting point of 138.5-140℃. The last step can also be carried out in propionitrile. 1,3-Dihalogen 2-(2,4-difluorophenyl)-2-propanol and 1H-1,2,4-triazole are refluxed in propionitrile under sodium hydroxide catalysis and PEG600 phase transfer catalysis to obtain crude fluconazole. The crude product is dissolved in fatty alcohol, heated to dissolve, decolorized with a small amount of activated carbon, and cooled to obtain crystals, which are the fine fluconazole with a melting point of 139-140°C.
Product Specification
| Item | Specification | Result |
| Assay | 98% | 99.68% |
| Appearance | White to yellowish white crystalline powder | conforms |
| Odor | Characteristic | conforms |
| Taste | Characteristic | conforms |
| Particle Size | NLT 100% Through 80 mesh | conforms |
| Loss on Drying | <2.0% | 0.47% |
| Heavy metals | ||
| Total Heavy Metals | ≤10ppm | conforms |
| Arsenic | ≤3ppm | conforms |
| Lead | ≤3ppm | conforms |
| Microbiological Tests | ||
| Total Plate Count | ≤1000cfu/g | conforms |
| Total Yeast & Mold | ≤100cfu/g | conforms |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Conclusion | Conform with the enterprise standard | |
How To Obtain Samples Fluconazole powder?
Welcome to send an inquiry to sunny@faithfulbio.com at any time for a free sample if you need the API Fluconazole powder.
The Best Fluconazole powder Manufacturer And Supplier
Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
Why Choose Faithfulbio Fluconazole powder?
Faithfulbio specialize in Fluconazole powder for several years, we supply products at a competitive price, and our product is of the highest quality, because we are very strict in product production and testing, and have a complete and mature system. In addition, our employees The quotation for the product is very competitive.
A variety of shipping methods for you to choose
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Transportation Time |
Shipping method |
Cargo weight requirements |
Advantage |
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3-7 days |
DHL,Germany DHL,Germany DPD, |
Suitable for under 50kg. |
We have warehouses in Germany and California, USA, |
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7-15 days |
By Air |
Suitable for more than 50kg. |
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15-60 days |
By Sea |
Suitable for more than 500kg. |
kindly note: Use Fluconazole powderfor research purposes only. All compounds have risks. Please consult your doctor and learn about available studies before use. In addition, the above description of the compound comes from online literature. If there is any infringement, please contact us to delete it.
Where To Buy Fluconazole powder?
Just send an email to sunny@faithfulbio.com, or submit your requirement in the bottom form, we are of service at any time!
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