what is Ivabradine hydrochloride?
Ivabradine hydrochloride is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 μM, respectively).In vivo, ivabradine (10 mg/kg per day) reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction.Formulations containing ivabradine have been used in the treatment of heart failure and angina.
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Product name |
Ivabradine hydrochloride |
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CAS |
148849-67-6 |
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|
Molecular formula |
C27H37ClN2O5 | |
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Molecular weight |
505.05 | |
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EINECS Number |
638-798-3 | |
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Storage condition |
2-8°C | |
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Appearance |
white powder | |
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Melting point |
193-196degre | |
| Solubility | water:≥5mg/mL |
what are the use of Ivabradine hydrochloride?
Ivabradine hydrochloride is the first selective and specific heart rate inhibitor that has a selective effect on the sinoatrial node but no effect on intracardiac conduction, myocardial contraction, or ventricular repolarization
Ivabradine hydrochloride is a hydrochloride salt synthesized from an equal amount of one mole of hydrochloric acid and is used to treat patients with angina pectoris who cannot tolerate receptor blockers and/or heart failure.
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How about In vivo research of Ivabradine hydrochloride?
Ivabradine hydrochloride treatment (10mg/kg/d) induces long term HRR,and that improves diastolic LV function probably involving attenuated hypoxia,reduced remodeling,and or preserved nitric oxide bioavailability,resulting from processe striggered early after HRR initiation:angiogenesis and/or preservation of endothelial nitric oxide synthase expression.Ivabradine hydrochloride leads to a sustained15-20% heart rate reduction,but has no effecton blood pressure .While ivabradine has no effecton endothelial function and vascular reactive oxygen species production in angiotensinII-treated rats,it improves both parameters in ApoE knock outmice.Ivabradine hydrochloride treatment leads to an attenuation of angiotensinII signaling and increased the expression of telomere-stabilizing proteins in ApoE knock outmice,which may explain its beneficial effects on the vasculature.
Product Specification
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Items |
Specifications |
Results |
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Appearance |
White to off-white powder |
White powder |
|
Purity (HPLC) |
Not less than 99.0% |
99.87% |
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Max single impurity |
Not more than 0.1% |
0.05% |
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Total imputities |
Not more than 1.0% |
0.13% |
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Isomer |
Not more than 0.1% |
0.05% |
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Loss on Drying |
Not more than 1.0% |
0.58% |
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Moisture content |
Not more than 1.0% |
0.11% |
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Residues On Ignition |
Not more than 0.2% |
0.10% |
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Heavy Metals |
Not more than 20ppm |
Conforms |
|
Specific optical rotation |
+6.5°~ +8.5° |
+8.38° |
what is the Mechanism of action Ivabradine hydrochloride in the treatment of JET?
there have been reports demonstrating successful conversion of JET, both congenital and postoperative forms, to sinus rhythm with the use of ivabradineThe efficacy of ivabradine is hypothesized to bedue to its effect on inhibiting the cardiac pacemaker funny(If) current and thereby reducing automaticity, which is oneof the main mechanisms of this arrhythmia.
This potential new indication of ivabradine was first reported by Al-Ghamdi in a 2-year-old child with refractory congenital JET
Subsequently, there were 2 small case series reporting the successful use of ivabradine in children with postoperative JET. The safety of ivabradine is reasonably well established in adults with chronic heart failure and in children there is accumulating experience with the use of ivabradine
Does Ivabradine hydrochloride cause adverse reactions?
The most common adverse reactions are flash phenomenon (photophobia) and bradycardia, which are dose-dependent and related to the pharmacological effects of Ivabradine hydrochloride.
Common adverse reactions include neurological disorders such as dizziness and headache; Blurred vision; Heart diseases such as bradycardia, first-degree atrioventricular block, ventricular premature contractions, and atrial fibrillation; Poor blood pressure control.
Uncommon or rare adverse reactions include: eosinophilia, hyperuricemia, syncope, diplopia, visual impairment, palpitations, supraventricular premature contractions, hypotension, dyspnea, nausea, vomiting, diarrhea, angioedema, rash, muscle spasms, elevated creatinine, etc.
How and where to buy Ivabradine hydrochloride wholesale?
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Shipping method |
Cargo weight requirements |
Advantage |
|
3-7 days |
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Suitable for under 50kg. |
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By Air |
Suitable for more than 50kg. |
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Suitable for more than 500kg. |
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