Imeglimin Hydrochloride API CAS 775351-61-6

Imegramine hydrochloride Introduction

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Imeglimin hydrochloride API (CAS 775351-61-6) is a novel, orally active small molecule compound with a molecular weight of 191.66. Imegramine hydrochloride was originally developed by Sumitomo Pharmaceutical in Japan. Its synthesis process involves steps such as the chiral resolution of the racemic form Imeglimin. In terms of application, it is mainly used as a tool molecule for exploring the regulatory mechanisms of mitochondrial function, and is widely used in cell models related to glucose metabolism balance. Studies have shown that Imegramine hydrochloride can regulate the activity of the mitochondrial respiratory chain complex in cells, thereby affecting the energy metabolism state of the cells. These characteristics make it a valuable tool in the study of pathological mechanisms related to metabolic abnormalities.

In which direction was Imegramine hydrochloride mainly studied?

The research on Imegramine hydrochloride mainly focuses on the regulation of mitochondrial function. Mitochondria are like the "energy factory" of cells, responsible for converting nutrients into energy that cells can utilize. In some metabolic-related research models, it was found that mitochondrial dysfunction leads to a decrease in the efficiency of cells' utilization of glucose, accompanied by the accumulation of harmful reactive oxygen species. The action characteristics of Imeglimin hydrochloride API lie in its ability to simultaneously affect multiple links involved in energy balance - on the one hand, it acts on the pancreatic cells that secrete insulin to regulate signals, and on the other hand, it also affects the glucose utilization process in the liver and skeletal muscles. This multi-targeted action feature has drawn attention in the exploration of metabolic regulation networks.

What is the mechanism of action of imegramine hydrochloride?

The action mechanism of Imegramine hydrochloride lies in the regulation of energy metabolism at the mitochondrial level. The main target of Imegramine hydrochloride within the cells is several key complexes on the respiratory chain. By moderately adjusting the active states of these complexes, it can alleviate the accumulation of oxidative stress caused by a high sugar environment. This regulation has direct protective significance for pancreatic β cells - after the oxidative stress is reduced, the secretion function of the cells can be maintained to a certain extent, especially under glucose stimulation, the insulin release efficiency will significantly increase. At the same time, the Imeglimin hydrochloride API also exhibits different modes of action in the liver and skeletal muscle: in the liver, it can inhibit the gluconeogenesis process and reduce the generation of endogenous glucose; in the skeletal muscle, it helps to improve the conduction efficiency of the insulin signaling pathway, making the peripheral tissues more sensitive to insulin stimulation. This dual mechanism that acts on both the pancreas and peripheral tissues forms the basis for its coordinated regulation of overall glucose metabolism. Additionally, studies have suggested that it may also participate in the activation of the NAD⁺ salvage synthesis pathway, by increasing the intracellular NAD⁺ level to improve the overall energy response. This auxiliary pathway also provides more possibilities for exploring its application in metabolic disorder-related models.

MF of Imegramine hydrochloride

CAS	775351-61-6
Molecular formula	C6H14ClN5
Molecular weight	191.66186
Form	Solid
Color	White to off-white
Solubility	Water content ≥ 62.7 mg/mL

            

Specification

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FAQ: 

Q1:What is the main metabolic pathway of Imegramine hydrochloride?
Its main metabolic pathway is the N-demethylation reaction. The metabolites exist in free form. The metabolic process involves a relatively small number of cytochrome P450 enzyme subtypes.
Q2:What is the cell-penetrating ability of Imegramine hydrochloride? Is it easy to enter the cells?

It carries a positive charge under physiological pH conditions, has a low logP value, and good water solubility. It is speculated to enter the cell mainly through a specific transporter-mediated process rather than simple free diffusion.

Q3:Does Imegramine hydrochloride exhibit different effects under hypoxic conditions compared to normal oxygen conditions?

Some literature reports indicate that under hypoxic conditions, the mitochondrial respiratory chain is already in a state of inhibition. When Imegramine hydrochloride is added at this time, a synergistic effect may occur, but the extent of its effect is significantly less than the basic effect under normoxic conditions.

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