Ritalinic Acid CAS 19395-41-6

Ritalinic acid is the core metabolite formed from methylphenidate through natural biotransformation in vivo. It is also the most abundant and stable terminal metabolite in the metabolic pathway of this class of compounds. Under normal environmental conditions of temperature and pressure, this substance exists as a homogeneous white crystalline powder. Its solubility exhibits significant solvent selectivity, dissolving efficiently in a variety of polar organic solvents, but its solubility in pure water is extremely poor. It also possesses a fixed melting range and standard relative molecular mass, and its physicochemical properties are very stable. In normal biological metabolic mechanisms, esterases, widely present in the body, conduct a mild catalytic hydrolysis reaction on the corresponding parent compound, causing the ester bonds of the parent molecule to break and undergo structural remodeling. Ultimately, the vast majority of the parent component is naturally converted into ritalinic acid.

Ritalinic acid is a biologically inactive transformation product, possessing no central nervous system regulatory effects. It does not interfere with or affect the normal state of the body's nervous system, can remain stably in the body, and is subsequently slowly decomposed and excreted through the body's natural metabolic cycle. Compared to its original parent component, litaxelic acid exhibits a significantly longer retention time in vivo, a higher steady-state concentration, and more prominent biomarkers, making it a highly specific metabolic biomarker. Leveraging its unique advantages such as structural stability, strong anti-interference ability, long detection window, and high biorecognition, this substance is currently widely used in various scientific research fields, including the study of metabolic kinetics, qualitative and quantitative analysis of biological samples, and research on the fundamental mechanisms of the nervous system. It is a commonly used standard control and precision internal standard in laboratories, effectively improving the accuracy and reliability of various experimental data.